FVB.Cg-Tg(Wap-Shh)119Mig/Cnbc

Status	Available to order
EMMA ID	EM:07013
Citation information	RRID:IMSR_EM:07013 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	FVB.Cg-Tg(Wap-Shh)119Mig/Cnbc
Alternative name	Tg(WAP-Shh)119Mig-FVB
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Wap-Shh)119Mig
Gene/Transgene symbol	Tg(Wap-Shh)119Mig

Information from provider

Provider	Marta Gallego
Provider affiliation	Patologia Mamaria, Instituto de Salud Carlos III
Genetic information	Transgenic mouse expressing mouse Shh under the WAP promoter.
Phenotypic information	Transgenic Shh expression in the secretory epithelium of the mouse mammary gland induces the expansion of ciliated cells that express diverse progenitor cell markers in the mammary basal epithelium. Mammary glands number 3 and 4 are fused on each side under the skin. Transgenic individuals have a kinky tail, which enables this trait to be used instead of specific genotyping.
Breeding history	It was generated in a (DBA/2 x C57BL/6)F1 background and backcrossed for 9 generations into FVB.
References	Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland.;García-Zaragoza Elena, Pérez-Tavarez Raquel, Ballester Alicia, Lafarga Vanesa, Jiménez-Reinoso Anaïs, Ramírez Angel, Murillas Rodolfo, Gallego Marta I, ;2012;Developmental biology;372;28-44; 23000969
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archiving	heterozygous FVB males, wild-type FVB/N females
Stage of embryos	2-cell

Literature references

Intraepithelial paracrine Hedgehog signaling induces the expansion of ciliated cells that express diverse progenitor cell markers in the basal epithelium of the mouse mammary gland.;García-Zaragoza Elena, Pérez-Tavarez Raquel, Ballester Alicia, Lafarga Vanesa, Jiménez-Reinoso Anaïs, Ramírez Angel, Murillas Rodolfo, Gallego Marta I, ;2012;Developmental biology;372;28-44; 23000969

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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