B6;129-Foxb1tm1Pgr/PgrKieg

Status

Available to order

EMMA IDEM:00071
Citation informationRRID:IMSR_EM:00071 

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International strain nameB6;129-Foxb1tm1Pgr/PgrKieg
Alternative nameFoxB1, B6.129/SvR1-FoxB1, FoxB1 KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolFoxb1tm1Pgr
Gene/Transgene symbolFoxb1

Information from provider

ProviderPeter Gruss
Provider affiliationMax Planck Inst. Biophysical Chemistry
Genetic information9 Kb 5' genomic fragment, followed by PGK-neo expression cassette and 1.6 Kb 3' genomic fragment, leading to replacement of the 3' part of exon 1 and the 5' part of exon 2, including the ATG and the forkhead domain-coding sequence.
Phenotypic informationHomozygous animals (3 weeks of age): midbrain malformations - inferior colliculi reduced near the midline and partially covered by anterior cerebellum, hypothalamic malformations - medial mammillary nucleus absent, other nuclei less compact (this phenotype starts to be detectable at E16.5 - 18.5). Mothers neglect their pups and show neither nest-building nor nursing activities.
References
  • Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body.;Wehr R, Mansouri A, de Maeyer T, Gruss P, ;1997;Development (Cambridge, England);124;4447-56; 9409663

Information from EMMA

Archiving centreKarolinska Institutet, Stockholm, Sweden

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal midbrain morphology / MGI
  • decreased inferior colliculus size / MGI
  • abnormal hypothalamus morphology / MGI
  • abnormal spatial learning / MGI
  • abnormal mammillary body morphology / MGI
  • behavior/neurological phenotype / MGI
  • abnormal spatial working memory / MGI
  • abnormal cerebellum morphology / MGI
  • abnormal cerebellum anterior vermis morphology / MGI
  • decreased body weight / MGI
  • abnormal nursing / MGI
  • abnormal maternal nurturing / MGI
  • postnatal growth retardation / MGI
  • maternal effect / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • decreased body size / MGI
  • abnormal sexual interaction / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
MGI phenotypes (gene matching)
  • abnormal mammary gland morphology / MGI
  • abnormal hypothalamus morphology / MGI
  • abnormal cerebellum morphology / MGI
  • abnormal cerebellum anterior vermis morphology / MGI
  • abnormal midbrain morphology / MGI
  • open neural tube / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal nursing / MGI
  • abnormal maternal nurturing / MGI
  • abnormal locomotor behavior / MGI
  • hypoactivity / MGI
  • abnormal gait / MGI
  • abnormal spatial learning / MGI
  • limb grasping / MGI
  • decreased embryo size / MGI
  • postnatal growth retardation / MGI
  • abnormal brain morphology / MGI
  • abnormal sexual interaction / MGI
  • no phenotypic analysis / MGI
  • nervous system phenotype / MGI
  • maternal effect / MGI
  • caudal body truncation / MGI
  • abnormal mammillary body morphology / MGI
  • behavior/neurological phenotype / MGI
  • abnormal spatial working memory / MGI
  • decreased survivor rate / MGI
  • decreased inferior colliculus size / MGI
  • abnormal mammary gland epithelium morphology / MGI
  • abnormal mammary gland lobule morphology / MGI
  • abnormal mammary gland alveolus morphology / MGI
  • decreased grip strength / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • preweaning lethality, incomplete penetrance / MGI
  • galactostasis / MGI

Literature references

  • Fkh5-deficient mice show dysgenesis in the caudal midbrain and hypothalamic mammillary body.;Wehr R, Mansouri A, de Maeyer T, Gruss P, ;1997;Development (Cambridge, England);124;4447-56; 9409663

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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