IMPC phenotypes (gene matching)
B6.129P2-Nrcamtm1Fgr/Orl
| Status | Available to order |
| EMMA ID | EM:00728 |
| Citation information | RRID:IMSR_EM:00728 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Nrcamtm1Fgr/Orl |
| Alternative name | NrCAM -/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Nrcamtm1Fgr |
| Gene/Transgene symbol | Nrcam |
Information from provider
| Provider | Margret Morè |
| Provider affiliation | MDC |
| Genetic information | A neo cassette replaces the ATG-containing exon of the Nrcam gene; the knock-out mutation results in the absence of NRCAM protein. |
| Phenotypic information | Nrcam -/- mice have all eye lens cataract. They also have minor motor defects, and a slightly abnormal cerebellum. Female -/- mice generally do not care for their pups. Other, not yet analyzed, defects may be present. |
| References |
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Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
Disease and phenotype information
MGI phenotypes (gene matching)
- small cerebellum / MGI
- abnormal myelination / MGI
- decreased body weight / MGI
- abnormal social investigation / MGI
- impaired coordination / MGI
- abnormal gait / MGI
- abnormal spatial learning / MGI
- abnormal learning/memory/conditioning / MGI
- disorganized secondary lens fibers / MGI
- decreased vertical activity / MGI
- abnormal motor learning / MGI
- abnormal locomotor activation / MGI
- nervous system phenotype / MGI
- abnormal axon morphology / MGI
- abnormal neurite morphology / MGI
- decreased nerve conduction velocity / MGI
- decreased prepulse inhibition / MGI
- decreased grip strength / MGI
- nuclear cataracts / MGI
- heart block / MGI
- abnormal node of Ranvier morphology / MGI
Literature references
- Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation.;Moré M I, Kirsch F P, Rathjen F G, ;2001;The Journal of cell biology;154;187-96; 11449000