MGI phenotypes (allele matching)
- abnormal circulating C-reactive protein level / MGI
B6.Cg-Crptm1Hjf/Ieg
| Status | Available to order |
| EMMA ID | EM:07285 |
| Citation information | RRID:IMSR_EM:07285 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Crptm1Hjf/Ieg |
| Alternative name | B6.CRP-tm1Hjf |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Crptm1Hjf |
| Gene/Transgene symbol | Crp |
Information from provider
| Provider | Hans Joerg Fehling |
| Provider affiliation | Molecular Immunology, Institute for Immunology |
| Genetic information | Mice with constitutively inactivated CRP alleles were generated with C57BL/6-derived Bruce 4 ES cells by classical gene targeting. All coding sequences of the CRP gene are deleted and replaced by a loxP-flanked Neo-cassette, except for the first 11 triplets encoding the N-terminal part of the signal peptide. |
| Phenotypic information | Mice homozygous for a knock-out allele lack detectable C-reactive protein in the serum but are otherwise healthy and fertile. |
| Breeding history | Generated in C57BL/6-derived Bruce 4 ES cells and always maintained on C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | homozygous C57BL/6N males |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal circulating C-reactive protein level / MGI
Literature references
- No reduction of atherosclerosis in C-reactive protein (CRP)-deficient mice.;Teupser Daniel, Weber Odile, Rao Tata Nageswara, Sass Kristina, Thiery Joachim, Fehling Hans Jörg, ;2011;The Journal of biological chemistry;286;6272-9; 21149301