B6.Cg-Per3tm1.1(PER3)Sarc/H
| Status | Available to order |
| EMMA ID | EM:07292 |
| Citation information | RRID:IMSR_EM:07292 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Per3tm1.1(PER3)Sarc/H |
| Alternative name | PER3 VNTR 4 |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Per3tm1.1(PER3)Sarc |
| Gene/Transgene symbol | Per3 |
Information from provider
| Provider | Simon Archer |
| Provider affiliation | SBMS/EBU, University of Surrey |
| Genetic information | Humanised knock-in mice conditional for the 4-repeat allele of the PERIOD3 variable number tandem repeat (VNTR) polymorphism |
| Phenotypic information | Normal circadian behaviour, altered sleep homeostasis |
| Breeding history | Inbred, ~40 generations |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial advanced sleep-phase syndrome / Orphanet_164736
Literature references
- A human sleep homeostasis phenotype in mice expressing a primate-specific PER3 variable-number tandem-repeat coding-region polymorphism.;Hasan Sibah, van der Veen Daan R, Winsky-Sommerer Raphaelle, Hogben Alexandra, Laing Emma E, Koentgen Frank, Dijk Derk-Jan, Archer Simon N, ;2014;FASEB journal : official publication of the Federation of American Societies for Experimental Biology;28;2441-54; 24577121