B6.Cg-Tg(Cd68-BCL2)526Medz/Biat

Status	Available to order
EMMA ID	EM:07303
Citation information	RRID:IMSR_EM:07303 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.Cg-Tg(Cd68-BCL2)526Medz/Biat
Alternative name	C57BL6/J-Tg(hbcl2)526rm
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Cd68-BCL2)526Medz
Gene/Transgene symbol	Tg(Cd68-BCL2)526Medz

Information from provider

Provider	Amanda Jamieson
Provider affiliation	Ruslan Medzhitov/Department of Immunobiology, Yale University
Additional owner	Ruslan Medzhitov, Yale University, New Haven CT, USA
Genetic information	Random insertion and overexpression of human bcl-2 under the control of the CD68 promoter.
Phenotypic information	Myeloid cell types are resistant to apoptotic stimuli; heightened inflammatory response; lower expression levels than C57BL/6J-Tg(hbcl2)535rm.
Breeding history	Backcrossed more than 30 generations to C57BL/6J. Female heterozygous mice have very low fertility so no homozygous mice have been made. All breeding has been done with transgenic males and C57BL/6J females.
References	Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila.;Nogueira Catarina V, Lindsten Tullia, Jamieson Amanda M, Case Christopher L, Shin Sunny, Thompson Craig B, Roy Craig R, ;2009;PLoS pathogens;5;e1000478; 19521510
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	University of Veterinary Medicine, Vienna, Austria
Animals used for archiving	heterozygous C57BL/6J males, wild-type C57BL/6J females
Stage of embryos	2-cell

Literature references

Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila.;Nogueira Catarina V, Lindsten Tullia, Jamieson Amanda M, Case Christopher L, Shin Sunny, Thompson Craig B, Roy Craig R, ;2009;PLoS pathogens;5;e1000478; 19521510

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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