B6.Cg-Tg(Cd68-BCL2)533Medz/Biat
| Status | Available to order |
| EMMA ID | EM:07304 |
| Citation information | RRID:IMSR_EM:07304 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(Cd68-BCL2)533Medz/Biat |
| Alternative name | C57BL6/J-Tg(hbcl2)snglrm |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Cd68-BCL2)533Medz |
| Gene/Transgene symbol | Tg(Cd68-BCL2)533Medz |
Information from provider
| Provider | Amanda Jamieson |
| Provider affiliation | Ruslan Medzhitov/Department of Immunobiology, Yale University |
| Additional owner | Ruslan Medzhitov, Yale University, New Haven CT, USA |
| Genetic information | Random insertion and overexpression of human bcl-2 under the control of the CD68 promoter. |
| Phenotypic information | Decreased myeloid cell numbers; later erupting molars; premature greying of hair. |
| Breeding history | Backcrossed more than 30 generations to C57BL/6J. Female heterozygous mice have very low fertility so no homozygous mice have been made. All breeding has been done with transgenic males and C57BL/6J females. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | heterozygous C57BL/6J males |
Literature references
- Rapid pathogen-induced apoptosis: a mechanism used by dendritic cells to limit intracellular replication of Legionella pneumophila.;Nogueira Catarina V, Lindsten Tullia, Jamieson Amanda M, Case Christopher L, Shin Sunny, Thompson Craig B, Roy Craig R, ;2009;PLoS pathogens;5;e1000478; 19521510