MGI phenotypes (allele matching)
B6.129-Pdgfatm2Cbet/Kctt
| Status | Available to order |
| EMMA ID | EM:07305 |
| Citation information | RRID:IMSR_EM:07305 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Pdgfatm2Cbet/Kctt |
| Alternative name | Pdgfa-ex6 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Pdgfatm2Cbet |
| Gene/Transgene symbol | Pdgfa |
Information from provider
| Provider | Johanna Andrae |
| Provider affiliation | Immunologi, genetik och patologi |
| Genetic information | Site-specific mutation of the splice acceptor site in exon 6. Prevents splicing into exon 6, and generates only the short splice variant of Pdgfa. |
| Phenotypic information | No overt phenotype. |
| Breeding history | Generated as mixed 129/Sv;C57BL/6. Backcrossed to C57BL/6 for more than 10 generations. Currently bred as heterozygotes or homozygotes. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | homozygous C57BL/6 males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- heart right ventricle hypertrophy / MGI
- abnormal small intestine morphology / MGI
- arrest of spermatogenesis / MGI
- abnormal spermatogenesis / MGI
- abnormal lung morphology / MGI
- atelectasis / MGI
- lung hemorrhage / MGI
- absent pulmonary alveoli / MGI
- decreased body size / MGI
- postnatal growth retardation / MGI
- respiratory failure / MGI
- emphysema / MGI
- premature death / MGI
- abnormal epididymis morphology / MGI
- thick ventricular wall / MGI
- abnormal pulmonary elastic fiber morphology / MGI
- decreased fetal size / MGI
- fetal growth retardation / MGI
- enlarged thoracic cavity / MGI
- abnormal epididymis epithelium morphology / MGI
- respiratory system phenotype / MGI
- impaired lung alveolus development / MGI
- mortality/aging / MGI
- pneumothorax / MGI
- abnormal pulmonary interalveolar septum morphology / MGI
- abnormal pulmonary alveolar parenchyma morphology / MGI
- postnatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased small intestinal villus number / MGI
Literature references
- Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A.;Andrae Johanna, Ehrencrona Hans, Gallini Radiosa, Lal Mark, Ding Hao, Betsholtz Christer, ;2013;Molecular and cellular biology;33;4030-40; 23938297