| Status | Available to order |
| EMMA ID | EM:07434 |
| Citation information | RRID:IMSR_EM:07434 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6JOlaHsd.129-Loxtm1Soin/Oulu |
| Alternative name | Lox |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Loxtm1Soin |
| Gene/Transgene symbol | Lox |
| Provider | Joni Maki |
| Provider affiliation | Department of Medical Biochemistry and Molecular Biology, University of Oulu |
| Additional owner | Strain is owned by University of Oulu |
| Genetic information | Deletion of lysyl oxidase gene, Lox+/-. This strain is on C57BL/6JOlaHsd background. The C57BL/6JOlaHsd substrain differs from other C57BL/6J substrains, as it carries a deletion in the Snca gene that is not present in any other B6 substrain. The Snca mutation may be of importance e.g. for studies on Parkinson’s disease. Most C57BL/6J mice have a deletion in the nicotinamide nucleotide transhydrogenase (Nnt) gene that results in inappropriate glucose homeostasis in B6J male mice; the C57BL/6JOlaHsd substrain resembles C57BL/6N lines, which do not carry this Nnt mutation. |
| Phenotypic information | Cardiovascular phenotype, respiratory system phenotype, perinatal lethality. |
| Breeding history | C57BL/6JOlaHsd, over hundred generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd males, wild-type C57BL/6JOlaHsd females |
| Stage of embryos | 2-cell |
Orphanet associated rare diseases, based on orthologous gene matching
