MGI phenotypes (allele matching)
- homeostasis/metabolism phenotype / MGI
B6;129P2-Hspg2tm1Soin/Oulu
| Status | Available to order |
| EMMA ID | EM:07460 |
| Citation information | RRID:IMSR_EM:07460 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Hspg2tm1Soin/Oulu |
| Alternative name | Hspg2 (tm1Soin) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Hspg2tm1Soin |
| Gene/Transgene symbol | Hspg2 |
Information from provider
| Provider | Raija Soininen |
| Provider affiliation | Biocenter Oulu, University of Oulu |
| Additional owner | Stra?n was generated in the laboratory of prof. Karl Tryggvason. |
| Genetic information | Hspg2tm1Soin |
| Phenotypic information | Homeostasis/metabolism; vision/eye. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd males, wild-type C57BL/6JOlaHsd females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Schwartz-Jampel syndrome / Orphanet_800
- Dyssegmental dysplasia, Silverman-Handmaker type / Orphanet_1865
MGI phenotypes (gene matching)
- abnormal inner ear morphology / MGI
- abnormal middle ear morphology / MGI
- delayed bone ossification / MGI
- abnormal bone marrow cavity morphology / MGI
- absent neurocranium / MGI
- short mandible / MGI
- abnormal ethmoid bone morphology / MGI
- abnormal sphenoid bone morphology / MGI
- cleft palate / MGI
- abnormal trabecular bone morphology / MGI
- abnormal long bone epiphysis morphology / MGI
- abnormal long bone metaphysis morphology / MGI
- abnormal vertebral body morphology / MGI
- abnormal rib morphology / MGI
- abnormal sternum morphology / MGI
- abnormal cartilage morphology / MGI
- abnormal cartilage development / MGI
- abnormal long bone hypertrophic chondrocyte zone / MGI
- abnormal chondrocyte morphology / MGI
- abnormal pericardium morphology / MGI
- abnormal craniofacial morphology / MGI
- abnormal cranium morphology / MGI
- domed cranium / MGI
- short snout / MGI
- short limbs / MGI
- abnormal forelimb morphology / MGI
- abnormal hindlimb morphology / MGI
- enlarged liver sinusoidal spaces / MGI
- abnormal telencephalon morphology / MGI
- exencephaly / MGI
- demyelination / MGI
- abnormal neuromuscular synapse morphology / MGI
- lung hemorrhage / MGI
- decreased body length / MGI
- decreased body weight / MGI
- delayed eyelid opening / MGI
- microphthalmia / MGI
- abnormal gait / MGI
- irregular heartbeat / MGI
- decreased embryo size / MGI
- hemorrhage / MGI
- intracranial hemorrhage / MGI
- respiratory failure / MGI
- premature death / MGI
- abnormal muscle morphology / MGI
- abnormal brain morphology / MGI
- abnormal bone marrow morphology / MGI
- disproportionate dwarf / MGI
- chondrodystrophy / MGI
- abnormal semilunar valve morphology / MGI
- abnormal aortic valve morphology / MGI
- abnormal pulmonary valve morphology / MGI
- abnormal endplate potential / MGI
- abnormal joint morphology / MGI
- impaired basement membrane formation / MGI
- abnormal long bone epiphyseal plate morphology / MGI
- abnormal skeletal muscle fiber morphology / MGI
- short femur / MGI
- aneurysm / MGI
- abnormal locomotor coordination / MGI
- increased width of hypertrophic chondrocyte zone / MGI
- osteoarthritis / MGI
- abnormal nervous system morphology / MGI
- abnormal long bone epiphyseal plate proliferative zone / MGI
- abnormal long bone morphology / MGI
- abnormal bone structure / MGI
- abnormal myelin sheath morphology / MGI
- abnormal myocardium compact layer morphology / MGI
- transposition of great arteries / MGI
- abnormal chest morphology / MGI
- abnormal muscle electrophysiology / MGI
- increased compact bone thickness / MGI
- abnormal spine curvature / MGI
- abnormal basement membrane morphology / MGI
- bowed humerus / MGI
- absent frontal bone / MGI
- absent parietal bone / MGI
- short nasal bone / MGI
- abnormal pelvic girdle bone morphology / MGI
- enlarged vertebral body / MGI
- decreased length of long bones / MGI
- abnormal vertebral column morphology / MGI
- abnormal cardinal vein morphology / MGI
- abnormal miniature endplate potential / MGI
- abnormal behavior / MGI
- abnormal osteoclast morphology / MGI
- increased osteoclast cell number / MGI
- abnormal intervertebral disk development / MGI
- hemopericardium / MGI
- abnormal occipital bone morphology / MGI
- abnormal humerus morphology / MGI
- abnormal myocardium layer morphology / MGI
- homeostasis/metabolism phenotype / MGI
- skeleton phenotype / MGI
- abnormal action potential / MGI
- abnormal axon morphology / MGI
- abnormal skeleton morphology / MGI
- abnormal cell physiology / MGI
- abnormal cardiac outflow tract development / MGI
- disorganized long bone epiphyseal plate / MGI
- increased diameter of long bones / MGI
- increased diameter of humerus / MGI
- abnormal bone ossification / MGI
- abnormal endochondral bone ossification / MGI
- decreased cranium height / MGI
- increased variability of skeletal muscle fiber size / MGI
- centrally nucleated skeletal muscle fibers / MGI
- abnormal skeletal muscle fiber type ratio / MGI
- skeletal muscle hyperplasia / MGI
- abnormal heart and great artery attachment / MGI
- abnormal ascending aorta and coronary artery attachment / MGI
- abnormal conotruncus septation / MGI
- absent conotruncal ridges / MGI
- conotruncal ridge hyperplasia / MGI
- abnormal node of Ranvier morphology / MGI
- abnormal paranode morphology / MGI
- abnormal internode morphology / MGI
- increased Schwann cell number / MGI
- mortality/aging / MGI
- perinatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- skin hemorrhage / MGI
- flat face / MGI
- decreased chondrocyte proliferation / MGI
- decreased bone mineralization / MGI
- abnormal radial glial cell endfoot morphology / MGI
- wide cranial sutures / MGI
- abnormal femur head morphology / MGI
- abnormal femur neck morphology / MGI
- short femur neck / MGI
Literature references
- Heparan sulfate in perlecan promotes mouse atherosclerosis: roles in lipid permeability, lipid retention, and smooth muscle cell proliferation.;Tran-Lundmark Karin, Tran Phan-Kiet, Paulsson-Berne Gabrielle, Fridén Vincent, Soininen Raija, Tryggvason Karl, Wight Thomas N, Kinsella Michael G, Borén Jan, Hedin Ulf, ;2008;Circulation research;103;43-52; 18596265
- Heparan sulfate chains of perlecan are indispensable in the lens capsule but not in the kidney.;Rossi Maarit, Morita Hiroyuki, Sormunen Raija, Airenne Sari, Kreivi Marjut, Wang Ling, Fukai Naomi, Olsen Bjorn R, Tryggvason Karl, Soininen Raija, ;2003;The EMBO journal;22;236-45; 12514129