B6.FVB-Tg(Krt14-Col18a1)J4Pih/Oulu

Status	Available to order
EMMA ID	EM:07461
Citation information	RRID:IMSR_EM:07461 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.FVB-Tg(Krt14-Col18a1)J4Pih/Oulu
Alternative name	K14-endostatin (J4) C57BL/6JOlaHsd
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(Krt14-Col18a1)J4Pih
Gene/Transgene symbol	Tg(Krt14-Col18a1)J4Pih

Information from provider

Provider	Taina Pihlajaniemi
Provider affiliation	Department of Medical Biochemistry and Molecular Biology, University of Oulu
Genetic information	Collagen XVIII-derived endostatin expressed under K14 promoter.
Phenotypic information	Phenotypes only observed in FVB/N strain (see EM:07462).
References	Endostatin overexpression specifically in the lens and skin leads to cataract and ultrastructural alterations in basement membranes.;Elamaa Harri, Sormunen Raija, Rehn Marko, Soininen Raija, Pihlajaniemi Taina, ;2005;The American journal of pathology;166;221-9; 15632014 Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice.;Brideau Gaëlle, Mäkinen Markus J, Elamaa Harri, Tu Hongmin, Nilsson Gunnar, Alitalo Kari, Pihlajaniemi Taina, Heljasvaara Ritva, ;2007;Cancer research;67;11528-35; 18089781 Lack of collagen XVIII accelerates cutaneous wound healing, while overexpression of its endostatin domain leads to delayed healing.;Seppinen Lotta, Sormunen Raija, Soini Ylermi, Elamaa Harri, Heljasvaara Ritva, Pihlajaniemi Taina, ;2008;Matrix biology : journal of the International Society for Matrix Biology;27;535-46; 18455382
Homozygous fertile	yes
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	University of Oulu, Oulu, Finland
Animals used for archiving	heterozygous C57BL/6JOlaHsd males, wild-type C57BL/6JOlaHsd females
Stage of embryos	2-cell

Literature references

Endostatin overexpression specifically in the lens and skin leads to cataract and ultrastructural alterations in basement membranes.;Elamaa Harri, Sormunen Raija, Rehn Marko, Soininen Raija, Pihlajaniemi Taina, ;2005;The American journal of pathology;166;221-9; 15632014
Endostatin overexpression inhibits lymphangiogenesis and lymph node metastasis in mice.;Brideau Gaëlle, Mäkinen Markus J, Elamaa Harri, Tu Hongmin, Nilsson Gunnar, Alitalo Kari, Pihlajaniemi Taina, Heljasvaara Ritva, ;2007;Cancer research;67;11528-35; 18089781
Lack of collagen XVIII accelerates cutaneous wound healing, while overexpression of its endostatin domain leads to delayed healing.;Seppinen Lotta, Sormunen Raija, Soini Ylermi, Elamaa Harri, Heljasvaara Ritva, Pihlajaniemi Taina, ;2008;Matrix biology : journal of the International Society for Matrix Biology;27;535-46; 18455382

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

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Practical information

Genotyping protocol

Example health report
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Material Transfer Agreement (MTA)
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EMMA conditions
Legally binding conditions for the transfer

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