MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
C3HeB/FeJ-Stk4m1Mhda/Ieg
| Status | Available to order |
| EMMA ID | EM:07465 |
| Citation information | RRID:IMSR_EM:07465 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3HeB/FeJ-Stk4m1Mhda/Ieg |
| Alternative name | C3HeB/FeJ-Stk4V263GMhdA/ieg, C3HeB/FeJ-Stk4V263GMhdA/Ieg |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Stk4m1Mhda |
| Gene/Transgene symbol | Stk4 |
Information from provider
| Provider | Sibylle Sabrautzki |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH) |
| Genetic information | Missense mutation in exon 7 of Stk4 c.788T->G, p.V263G |
| Phenotypic information | Heterozygous mice with no obvious phenotype, immunological phenotypes not analyzed; homozygous mice not analyzed; OMIM 614868 described for STK4, but was not analyzed. |
| Breeding history | More than 5 generations on pure C3HeB/FeJ background. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C3H males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Combined immunodeficiency due to STK4 deficiency / Orphanet_314689
MGI phenotypes (gene matching)
- increased neutrophil cell number / MGI
- thymus hyperplasia / MGI
- increased thymocyte number / MGI
- abnormal humoral immune response / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal dendritic cell physiology / MGI
- abnormal Peyer's patch germinal center morphology / MGI
- abnormal Peyer's patch T cell area morphology / MGI
- abnormal T cell physiology / MGI
- abnormal B cell physiology / MGI
- decreased IgD level / MGI
- increased IgM level / MGI
- increased IgE level / MGI
- abnormal immune system organ morphology / MGI
- no phenotypic analysis / MGI
- abnormal leukocyte migration / MGI
- abnormal leukocyte adhesion / MGI
- abnormal CD8-positive, alpha-beta T cell physiology / MGI
- decreased B-1 B cell number / MGI
- decreased lymphocyte cell number / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- increased T cell proliferation / MGI
- increased macrophage cell number / MGI
- abnormal CD4-positive, alpha-beta T cell physiology / MGI
- increased T cell apoptosis / MGI
- increased NK cell number / MGI
- abnormal memory T cell number / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased single-positive T cell number / MGI
- decreased single-positive T cell number / MGI
- decreased myeloid dendritic cell number / MGI
- increased dendritic cell number / MGI
- increased B-1b cell number / MGI
- abnormal marginal zone B cell morphology / MGI
- decreased marginal zone B cell number / MGI
- decreased B-2 B cell number / MGI
- abnormal spleen B cell follicle morphology / MGI
- decreased spleen white pulp amount / MGI
- increased interferon-gamma secretion / MGI
- increased interleukin-2 secretion / MGI
- increased interleukin-4 secretion / MGI
- increased histiocytic sarcoma incidence / MGI
- mortality/aging / MGI
- increased central memory CD4-positive, alpha-beta T cell number / MGI
- increased effector memory CD4-positive, alpha-beta T cell number / MGI
- increased central memory CD8 positive, alpha-beta T cell number / MGI
- increased effector memory CD8-positive, alpha-beta T cell number / MGI
- decreased CD8-positive, naive alpha-beta T cell number / MGI