MGI phenotypes (allele matching)
C3H;C-Gena127/H
| Status | Available to order |
| EMMA ID | EM:00079 |
| Citation information | RRID:IMSR_EM:00079 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3H;C-Gena127/H |
| Alternative name | GENA127 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Gena127 |
| Gene/Transgene symbol | Gena127 |
Information from provider
| Provider | Pat Nolan |
| Provider affiliation | MRC Mammalian Genetics Unit |
| Phenotypic information | Heterozygotes have a pigmentation defect where the coat is lighter than agouti. Outcrosses of heterozygotes to C3H/HeH produced 85 light coated offspring out of 194 pups scored indicating that the penetrance of Gena127 and viability of heterozygotes is good. Intercrosses of heterozygotes failed to produce any pups with a more extreme phenotype than that of the heterozygote; with average litter size of 6.25 from intercrosses compared to 8.44 from outcrosses these data suggest that homozygotes are lethal prenatally. Note on Stocklist states that light coat is not due to a mutation at the steel locus, but no breeding data were found to confirm this statement. |
| References |
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Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191