MGI phenotypes (gene matching)
- embryonic lethality between implantation and somite formation, complete penetrance / MGI
B6.129P2-Mbd3tm2Bh/H
| Status | Available to order |
| EMMA ID | EM:08022 |
| Citation information | RRID:IMSR_EM:08022 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Mbd3tm2Bh/H |
| Alternative name | Mbd3 Ex1 Flox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Mbd3tm2Bh |
| Gene/Transgene symbol | Mbd3 |
Information from provider
| Provider | Brian Hendrich |
| Provider affiliation | Wellcome Trust - MRC Stem Cell Institute, University of Cambridge |
| Genetic information | LoxP sites flanking Exon 1 of the Mbd3 gene. |
| Phenotypic information | Homozygous:No phenotype of floxed mice.Heterozygous:Normal. |
| Breeding history | Homozygous intercross. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex.;Aguilera Cristina, Nakagawa Kentaro, Sancho Rocio, Chakraborty Atanu, Hendrich Brian, Behrens Axel, ;2011;Nature;469;231-5; 21196933
- The NuRD component Mbd3 is required for pluripotency of embryonic stem cells.;Kaji Keisuke, Caballero Isabel Martín, MacLeod Ruth, Nichols Jennifer, Wilson Valerie A, Hendrich Brian, ;2006;Nature cell biology;8;285-92; 16462733