B6.Cg-Tg(CEACAM5)2682Wzm/Ieg
| Status | Available to order |
| EMMA ID | EM:08163 |
| Citation information | RRID:IMSR_EM:08163 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(CEACAM5)2682Wzm/Ieg |
| Alternative name | CEA2682 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CEACAM5)2682Wzm |
| Gene/Transgene symbol | Tg(CEACAM5)2682Wzm |
Information from provider
| Provider | Wolfgang Zimmermann |
| Provider affiliation | Tumor Immunology Laboratory, LIFE Center, University Hospital, Ludwig-Maximilians University Muenchen |
| Genetic information | Transgene: cosmid insert (33 kb) with complete human carcinoembryonic antigen (CEA) into unknown chromosomal location. |
| Phenotypic information | No apparent phenotype; the transgene is expressed in epithelial tissues as found for humans (mostly gastrointestinal tract). |
| Breeding history | Since generation of transgenic strain, mice were backcrossed continuously to C57BL/6; more than 20 generations. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N males |
Literature references
- Mice transgenic for the human carcinoembryonic antigen gene maintain its spatiotemporal expression pattern.;Eades-Perner A M, van der Putten H, Hirth A, Thompson J, Neumaier M, von Kleist S, Zimmermann W, ;1994;Cancer research;54;4169-76; 8033149
- Carcinoembryonic antigen transgenic mouse models for immunotherapy and development of cancer vaccines.;Bhattacharya-Chatterjee Malaya, Saha Asim, Foon Kenneth A, Chatterjee Sunil K, ;2008;Current protocols in immunology;0;20.8.1-20.8.12; 18432635
- Balancing between antitumor efficacy and autoimmune pathology in T-cell-mediated targeting of carcinoembryonic antigen.;Bos Rinke, van Duikeren Suzanne, Morreau Hans, Franken Kees, Schumacher Ton N M, Haanen John B, van der Burg Sjoerd H, Melief Cornelis J M, Offringa Rienk, ;2008;Cancer research;68;8446-55; 18922918
- An oral TLR7 agonist is a potent adjuvant of DNA vaccination in transgenic mouse tumor models.;Dharmapuri S, Aurisicchio L, Neuner P, Verdirame M, Ciliberto G, La Monica N, ;2009;Cancer gene therapy;16;462-72; 18989354
- The antitumor and immunoadjuvant effects of IFN-alpha in combination with recombinant poxvirus vaccines.;Hance Kenneth W, Rogers Connie J, Zaharoff David A, Canter Daniel, Schlom Jeffrey, Greiner John W, ;2009;Clinical cancer research : an official journal of the American Association for Cancer Research;15;2387-96; 19276249
- Human-restricted bacterial pathogens block shedding of epithelial cells by stimulating integrin activation.;Muenzner Petra, Bachmann Verena, Zimmermann Wolfgang, Hentschel Jochen, Hauck Christof R, ;2010;Science (New York, N.Y.);329;1197-201; 20813953
- Combination therapy with local radiofrequency ablation and systemic vaccine enhances antitumor immunity and mediates local and distal tumor regression.;Gameiro Sofia R, Higgins Jack P, Dreher Matthew R, Woods David L, Reddy Goutham, Wood Bradford J, Guha Chandan, Hodge James W, ;2013;PloS one;8;e70417; 23894654