| Status | Available to order |
| EMMA ID | EM:08270 |
| Citation information | RRID:IMSR_EM:08270 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Cd3etm1Mal Prss16tm1.1Mal/Cnbc |
| Alternative name | TSSP KO CD3E KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd3etm1Mal, Prss16tm1.1Mal |
| Gene/Transgene symbol | Cd3e, Prss16 |
| Provider | Alice Carrier |
| Provider affiliation | Stress Cell, CRCM |
| Additional owner | Dr. Marie Malissen, Centre d'Immunologie de Marseille-Luminy (CIML), France |
| Genetic information | Deletion of Prss16 gene encoding thymus-specific serine protease (TSSP), on a CD3epsilon-deficient background. |
| Phenotypic information | Homozygous:Partial immunodeficiency (altered repertoire of CD4 T cells).Heterozygous:No phenotype |
| Breeding history | We already described the breeding history in our previous submission of this Prss16 knock-out on C57BL/6 and 129/Sv background (EMMA strain ID EM:01380). For the present submission on CD3epsilon-deficient background, we have crossed homozygous Prss16 knock-out on C57BL/6 background with CD3epsilon delta5 mice (EMMA strain ID EM:00047) provided by Marie Malissen (CIML, France). The resulting double knock-out mice are mandatory for T cells adoptive transfer experiments. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | yes |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6 males, homozygous C57BL/6 females |
| Stage of embryos | 2-cell |
Orphanet associated rare diseases, based on orthologous gene matching
