IMPC phenotypes (gene matching)
B6.129-Lama4tm1Ktry/Oulu
| Status | Available to order |
| EMMA ID | EM:08326 |
| Citation information | RRID:IMSR_EM:08326 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Lama4tm1Ktry/Oulu |
| Alternative name | Lama4(tm1KTry) |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Lama4tm1Ktry |
| Gene/Transgene symbol | Lama4 |
Information from provider
| Provider | Raija Soininen |
| Provider affiliation | Biocenter Oulu, University of Oulu |
| Additional owner | Prof. Karl Tryggvason, Karolinska Institutet, Stockholm, Sweden |
| Genetic information | Exons 1 and 2 have been replaced by the PGK-neo cassette. |
| Phenotypic information | Homozygous:Homozygotes for targeted null mutations exhibit impaired motor control of the hind limbs associated with improperly positioned synaptic active zones and junctional folds, and prenatal and neonatal hemorrhages associated with capillary defects.Heterozygous:none observed |
| Breeding history | Backcrossing into C57BL/6NCrl more than 10 generations, then transferred to another animal facility and breeding continued by sib-mating and occasionally to C57BL/6JOlaHsd. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd males, wild-type C57BL/6JOlaHsd females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Familial isolated dilated cardiomyopathy / Orphanet_154
MGI phenotypes (allele matching)
- enlarged heart / MGI
- abnormal myocardial fiber morphology / MGI
- tremors / MGI
- abnormal myelination / MGI
- decreased Schwann cell number / MGI
- ataxia / MGI
- limb grasping / MGI
- impaired swimming / MGI
- cardiac hypertrophy / MGI
- poor circulation / MGI
- hemorrhage / MGI
- heart left ventricle hypertrophy / MGI
- abnormal sciatic nerve morphology / MGI
- dilated heart left ventricle / MGI
- abnormal capillary morphology / MGI
- abnormal myelin sheath morphology / MGI
- abnormal ventral spinal root morphology / MGI
- abnormal dorsal spinal root morphology / MGI
- cardiac ischemia / MGI
- abnormal sinus arrhythmia / MGI
- enlarged myocardial fiber / MGI
- myocardial fiber degeneration / MGI
- hypoxia / MGI
- cardiomyopathy / MGI
- decreased heart rate / MGI
- decreased ventricle muscle contractility / MGI
- cardiac interstitial fibrosis / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- dilated capillary / MGI
- abnormal axon radial sorting / MGI
- decreased hematocrit / MGI
- jaundice / MGI
- decreased body weight / MGI
- impaired limb coordination / MGI
- impaired balance / MGI
- abnormal circulating bilirubin level / MGI
- anemia / MGI
- abnormal blood vessel morphology / MGI
- internal hemorrhage / MGI
- reticulocytosis / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- impaired basement membrane formation / MGI
- pallor / MGI
- lethargy / MGI
- neonatal lethality, incomplete penetrance / MGI
MGI phenotypes (gene matching)
- decreased hematocrit / MGI
- enlarged heart / MGI
- abnormal myocardial fiber morphology / MGI
- jaundice / MGI
- tremors / MGI
- abnormal myelination / MGI
- decreased Schwann cell number / MGI
- decreased body weight / MGI
- ataxia / MGI
- limb grasping / MGI
- impaired swimming / MGI
- impaired limb coordination / MGI
- impaired balance / MGI
- abnormal circulating bilirubin level / MGI
- anemia / MGI
- abnormal blood vessel morphology / MGI
- cardiac hypertrophy / MGI
- poor circulation / MGI
- internal hemorrhage / MGI
- hemorrhage / MGI
- heart left ventricle hypertrophy / MGI
- reticulocytosis / MGI
- abnormal sciatic nerve morphology / MGI
- dilated heart left ventricle / MGI
- decreased hemoglobin content / MGI
- decreased erythrocyte cell number / MGI
- impaired basement membrane formation / MGI
- abnormal capillary morphology / MGI
- pallor / MGI
- abnormal myelin sheath morphology / MGI
- abnormal ventral spinal root morphology / MGI
- abnormal dorsal spinal root morphology / MGI
- cardiac ischemia / MGI
- abnormal sinus arrhythmia / MGI
- enlarged myocardial fiber / MGI
- myocardial fiber degeneration / MGI
- hypoxia / MGI
- lethargy / MGI
- cardiomyopathy / MGI
- decreased heart rate / MGI
- decreased ventricle muscle contractility / MGI
- cardiac interstitial fibrosis / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- neonatal lethality, incomplete penetrance / MGI
- dilated capillary / MGI
- abnormal axon radial sorting / MGI
Literature references
- Deletion of the laminin alpha4 chain leads to impaired microvessel maturation.;Thyboll Jill, Kortesmaa Jarkko, Cao Renhai, Soininen Raija, Wang Ling, Iivanainen Antti, Sorokin Lydia, Risling Mårten, Cao Yihai, Tryggvason Karl, ;2002;Molecular and cellular biology;22;1194-202; 11809810
- Properly formed but improperly localized synaptic specializations in the absence of laminin alpha4.;Patton B L, Cunningham J M, Thyboll J, Kortesmaa J, Westerblad H, Edström L, Tryggvason K, Sanes J R, ;2001;Nature neuroscience;4;597-604; 11369940