IMPC phenotypes (gene matching)
B6.129-Plod3tm1Soin/Oulu
| Status | Available to order |
| EMMA ID | EM:08330 |
| Citation information | RRID:IMSR_EM:08330 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Plod3tm1Soin/Oulu |
| Alternative name | Plod3tm1Soin |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Plod3tm1Soin |
| Gene/Transgene symbol | Plod3 |
Information from provider
| Provider | Raija Soininen |
| Provider affiliation | Biocenter Oulu, University of Oulu |
| Additional owner | Prof. Johanna Myllyharju, University of Oulu, Faculty of Biochemistry and Molecular Medicine, Oulu, Finland |
| Genetic information | Beta galactosidase-PGK neo cassette inserted in-frame into exon 1 of the Plod3 gene. |
| Phenotypic information | Homozygous:Homozygous embryos are developmentally retarded and fragile after E8.5 and die around E9.5-E10. At E9.5 in cells from homozygous embryos the basement membranes are fragmented, the endoplasmic reticulum is dilated, and the Golgi complexes and lysosomes are enlarged.Heterozygous:no changes observed |
| Breeding history | N=10 backcrosses |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Connective tissue disorder due to lysyl hydroxylase-3 deficiency / Orphanet_300284
MGI phenotypes (gene matching)
- cleft palate / MGI
- abnormal cell morphology / MGI
- exencephaly / MGI
- abnormal lung morphology / MGI
- blistering / MGI
- abnormal epidermal layer morphology / MGI
- decreased embryo size / MGI
- intracranial hemorrhage / MGI
- abnormal eye morphology / MGI
- abnormal neural tube morphology / MGI
- impaired basement membrane formation / MGI
- abnormal Reichert's membrane morphology / MGI
- embryonic growth retardation / MGI
- abnormal skeleton morphology / MGI
- increased vasodilation / MGI
- abnormal vascular endothelial cell morphology / MGI
- abnormal cutaneous collagen fibril morphology / MGI
- abnormal preimplantation embryo development / MGI
- neonatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- prenatal lethality, incomplete penetrance / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
Literature references
- Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice.;Rautavuoma Kati, Takaluoma Kati, Sormunen Raija, Myllyharju Johanna, Kivirikko Kari I, Soininen Raija, ;2004;Proceedings of the National Academy of Sciences of the United States of America;101;14120-5; 15377789