MGI phenotypes (allele matching)
B6;129-P4ha1tm1Jomy/Oulu
| Status | Available to order |
| EMMA ID | EM:08331 |
| Citation information | RRID:IMSR_EM:08331 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-P4ha1tm1Jomy/Oulu |
| Alternative name | P4ha1tm1Jomy |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | P4ha1tm1Jomy |
| Gene/Transgene symbol | P4ha1 |
Information from provider
| Provider | Johanna Myllyharju |
| Provider affiliation | Faculty of Biochemistry and Molecular Medicine, University of Oulu |
| Genetic information | P4ha1 gene was disrupted by in-frame insertion of the lacZ-PGK neo cassette into exon 2. |
| Phenotypic information | Homozygous:Development is delayed after E9.0 and mice die between E10.5 and E11.5. At E10.5 capillary walls are frequently ruptured and usually empty of red blood cells. Total collagen prolyl-4 hydroxylase activity was about 20% of that in wt.Heterozygous:No abnormalities observed. Total collagen prolyl-4 hydroxylase activity was 55-74% of that in wt. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6JOlaHsd males |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice.;Holster Tiina, Pakkanen Outi, Soininen Raija, Sormunen Raija, Nokelainen Minna, Kivirikko Kari I, Myllyharju Johanna, ;2007;The Journal of biological chemistry;282;2512-9; 17135260
- Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures.;Wang Nan, Langfelder Peter, Stricos Matthew, Ramanathan Lalini, Richman Jeffrey B, Vaca Raymond, Plascencia Mary, Gu Xiaofeng, Zhang Shasha, Tamai T Katherine, Zhang Liguo, Gao Fuying, Ouk Koliane, Lu Xiang, Ivanov Leonid V, Vogt Thomas F, Lu Qing Richard, Morton A Jennifer, Colwell Christopher S, Aaronson Jeffrey S, Rosinski Jim, Horvath Steve, Yang X William, ;2022;Neuron;110;3318-3338.e9; 36265442