MGI phenotypes (gene matching)
B6;129-Slc34a3tm1.1Nhch/Ph
| Status | Available to order |
| EMMA ID | EM:08337 |
| Citation information | RRID:IMSR_EM:08337 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Slc34a3tm1.1Nhch/Ph |
| Alternative name | Slc34a3 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Slc34a3tm1.1Nhch |
| Gene/Transgene symbol | Slc34a3 |
Information from provider
| Provider | Nati Hernando |
| Provider affiliation | Physiology, University of Zurich-Irchel |
| Additional owner | Dr. Jürg Biber and Dr. Carsten A Wagner, University of Zurich-Irchel, Institute of Physiology, Zurich, Switzerland |
| Genetic information | Insertion of loxP sites within introns 3 and 12 of the Slc34a3/NaPi-IIc gene. |
| Phenotypic information | Homozygous:A kidney specific knock out was generated by breeding floxed Slc34a3 with Pax8rtTA-LC1 mice that harbour the Cre recombinase gene under the control of the Pax8 promoter (Traykova-Brauch, Nature Med 2008). Upon Cre activity induction with Doxycycline, no differences in terms of phosphate homeostasis were found between wild type and conditional homozygous Slc34a3 littermates (Myakala, AJP, 2014).Heterozygous:A kidney specific knock out was generated by breeding floxed Slc34a3 with Pax8rtTA-LC1 mice that harbour the Cre recombinase gene under the control of the Pax8 promoter (Traykova-Brauch, Nature Med 2008). Upon Cre activity induction with Doxycycline, no differences in terms of phosphate homeostasis were found between wild type and conditional heterozygous Slc34a3 littermates (Myakala, AJP, 2014). |
| Breeding history | Backcrossed to C57BL/6 (2 generations). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Hereditary hypophosphatemic rickets with hypercalciuria / Orphanet_157215
Literature references
- Renal-specific and inducible depletion of NaPi-IIc/Slc34a3, the cotransporter mutated in HHRH, does not affect phosphate or calcium homeostasis in mice.;Myakala Komuraiah, Motta Sarah, Murer Heini, Wagner Carsten A, Koesters Robert, Biber Jürg, Hernando Nati, ;2014;American journal of physiology. Renal physiology;306;F833-43; 24553430