MGI phenotypes (allele matching)
- no phenotypic analysis / MGI
C57BL/6-Tg(Sftpc-Grem1)105Mmyl/Oulu
| Status | Available to order |
| EMMA ID | EM:08364 |
| Citation information | RRID:IMSR_EM:08364 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Tg(Sftpc-Grem1)105Mmyl/Oulu |
| Alternative name | SPC-lox-gremlin1 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Sftpc-Grem1)105Mmyl |
| Gene/Transgene symbol | Tg(Sftpc-Grem1)105Mmyl |
Information from provider
| Provider | Marjukka Myllarniemi |
| Provider affiliation | Dept of clinical medicine, University of Helsinki |
| Genetic information | Transgenic mouse. loxP-NEO-stop-loxP-gremlin1 cassette cloned under SPC-promoter. Crossing with a cre recombinase-expressing line drives expression of gremlin in lung type II epithelial cells. |
| Phenotypic information | Homozygous:When crossed with Gt(ROSA)26Sor-creERT2 mice, gremlin expression is detected in lung type II epithelial cells. The mice are viable and show mild septal thickening and possible alveolar space enlargement at 6 months of age. When exposed to silica, significantly less inflammatory cell infiltrates are observed in lung tissue compared to wild type mice. No obvious alterations in histological fibrosis were noted after silica exposure.Heterozygous:When crossed with Gt(ROSA)26Sor-creERT2 mice, gremlin expression is detected in lung type II epithelial cells. The mice are viable and show mild septal thickening and possible alveolar space enlargement at 6 months of age. When exposed to silica, significantly less inflammatory cell infiltrates are observed in lung tissue compared to wild type mice. No obvious alterations in histological fibrosis were noted after silica exposure. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6N males, wild-type C57BL/6JOlaHsd females |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- no phenotypic analysis / MGI
Literature references
- Gremlin-1 Overexpression in Mouse Lung Reduces Silica-Induced Lymphocyte Recruitment - A Link to Idiopathic Pulmonary Fibrosis through Negative Correlation with CXCL10 Chemokine.;Koli Katri, Sutinen Eva, Rönty Mikko, Rantakari Pia, Fortino Vittorio, Pulkkinen Ville, Greco Dario, Sipilä Petra, Myllärniemi Marjukka, ;2016;PloS one;11;e0159010; 27428020