IMPC phenotypes (gene matching)
- abnormal uterus morphology / IMPC
STOCK Map3k8tm1.2Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:08371 |
| Citation information | RRID:IMSR_EM:08371 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Map3k8tm1.2Gkl/Flmg |
| Alternative name | B6-Map3k8 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Map3k8tm1.2Gkl |
| Gene/Transgene symbol | Map3k8 |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Al. Fleming |
| Genetic information | A three loxP targeting vector containing 5' and 3' homology arms with mouse Map3k8 (Tpl2) gene, a neomycin cassette flanked by loxP1 and loxP2 and exon 4 flanked by loxP2 and loxP3 was used for the generation of targeted mice through targeting of ES cells with vector and selection for homologous recombination. From mice bearing the homologous integration of targeting vector in the germ line both exon 4 and neomycin cassette were removed upon in vivo recombination by EIIa-Cre. |
| Phenotypic information | Homozygous:No overt phenotypeHeterozygous:No overt phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
MGI phenotypes (allele matching)
- abnormal colon morphology / MGI
- rectal hemorrhage / MGI
- increased tumor growth/size / MGI
- increased incidence of tumors by chemical induction / MGI
- diarrhea / MGI
- decreased tumor necrosis factor secretion / MGI
- increased physiological sensitivity to xenobiotic / MGI
- abnormal enterocyte proliferation / MGI
- abnormal enterocyte apoptosis / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased susceptibility to weight loss / MGI
- decreased colon length / MGI
MGI phenotypes (gene matching)
- abnormal colon morphology / MGI
- abnormal dendritic cell antigen presentation / MGI
- decreased IgE level / MGI
- abnormal cytokine secretion / MGI
- rectal hemorrhage / MGI
- increased tumor growth/size / MGI
- increased incidence of tumors by chemical induction / MGI
- abnormal response to infection / MGI
- diarrhea / MGI
- impaired natural killer cell mediated cytotoxicity / MGI
- increased T cell proliferation / MGI
- immune system phenotype / MGI
- decreased IgG1 level / MGI
- increased IgG2a level / MGI
- abnormal tumor necrosis factor secretion / MGI
- decreased tumor necrosis factor secretion / MGI
- decreased interferon-alpha secretion / MGI
- decreased interferon-beta secretion / MGI
- decreased interleukin-1 beta secretion / MGI
- increased interleukin-12b secretion / MGI
- decreased interleukin-6 secretion / MGI
- decreased susceptibility to endotoxin shock / MGI
- increased physiological sensitivity to xenobiotic / MGI
- abnormal enterocyte proliferation / MGI
- abnormal enterocyte apoptosis / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- decreased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased susceptibility to weight loss / MGI
- decreased macrophage cytokine production / MGI
- prenatal lethality, incomplete penetrance / MGI
- decreased colon length / MGI
Literature references
- Tpl2 regulates intestinal myofibroblast HGF release to suppress colitis-associated tumorigenesis.;Koliaraki Vasiliki, Roulis Manolis, Kollias George, ;2012;The Journal of clinical investigation;122;4231-42; 23064365