C3H.Cg-Celsr1^Scy/H

Status	Available to order
EMMA ID	EM:00084
Citation information	RRID:IMSR_EM:00084 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C3H.Cg-Celsr1^Scy/H
Alternative name	GENA175
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Celsr1^Scy
Gene/Transgene symbol	Celsr1

Information from provider

Provider	Pat Nolan
Provider affiliation	MRC Mammalian Genetics Unit
Phenotypic information	Mice carrying this mutation exhibit circling behaviour.
References	A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)

abnormal snout morphology / IMPC
abnormal startle reflex / IMPC
increased circulating HDL cholesterol level / IMPC
increased lean body mass / IMPC
increased circulating cholesterol level / IMPC
decreased circulating cholesterol level / IMPC
decreased circulating amylase level / IMPC
increased total body fat amount / IMPC
preweaning lethality, complete penetrance / IMPC

IMPC phenotypes (gene matching)

abnormal head morphology / IMPC
male infertility / IMPC
female infertility / IMPC
abnormal brain morphology / IMPC
abnormal spleen morphology / IMPC
enlarged testis / IMPC
cataract / IMPC
increased brain size / IMPC
increased total body fat amount / IMPC
abnormal tail morphology / IMPC
enlarged spleen / IMPC
abnormal snout morphology / IMPC
no spontaneous movement / IMPC
increased lean body mass / IMPC
abnormal skin morphology / IMPC
preweaning lethality, complete penetrance / IMPC
corneal opacity / IMPC
preweaning lethality, incomplete penetrance / IMPC
increased circulating HDL cholesterol level / IMPC
abnormal startle reflex / IMPC
increased circulating cholesterol level / IMPC
decreased lean body mass / IMPC
abnormal retina morphology / IMPC
abnormal testis morphology / IMPC
abnormal vitreous body morphology / IMPC
decreased circulating cholesterol level / IMPC
decreased circulating amylase level / IMPC
necrosis / IMPC

MGI phenotypes (allele matching)

craniorachischisis / MGI
spinning / MGI
head shaking / MGI
abnormal cochlear sensory epithelium morphology / MGI
abnormal organ of Corti supporting cell morphology / MGI
cochlear outer hair cell degeneration / MGI
abnormal orientation of outer hair cell stereociliary bundles / MGI
head bobbing / MGI
abnormal involuntary movement / MGI
incomplete rostral neuropore closure / MGI
absent eyelids / MGI
abnormal outer hair cell kinocilium morphology / MGI
perinatal lethality, complete penetrance / MGI

MGI phenotypes (gene matching)

abnormal hair follicle orientation / MGI
ruffled hair / MGI
kinked tail / MGI
cranioschisis / MGI
incomplete rostral neuropore closure / MGI
open neural tube / MGI
abnormal lung morphology / MGI
pulmonary hypoplasia / MGI
decreased body size / MGI
absent eyelids / MGI
circling / MGI
head bobbing / MGI
spinning / MGI
abnormal coat appearance / MGI
increased susceptibility to otitis media / MGI
hydroencephaly / MGI
reduced fertility / MGI
deafness / MGI
prenatal lethality / MGI
delayed neural tube closure / MGI
head shaking / MGI
curly tail / MGI
testicular atrophy / MGI
abnormal cochlear sensory epithelium morphology / MGI
abnormal involuntary movement / MGI
small lung / MGI
abnormal neural tube closure / MGI
abnormal organ of Corti supporting cell morphology / MGI
abnormal respiratory conducting tube morphology / MGI
cochlear outer hair cell degeneration / MGI
abnormal orientation of outer hair cell stereociliary bundles / MGI
head tossing / MGI
abnormal neural plate morphology / MGI
dilated terminal bronchiole tubes / MGI
impaired hearing / MGI
abnormal lung epithelium morphology / MGI
craniorachischisis / MGI
whorled hair / MGI
abnormal lung saccule morphology / MGI
abnormal lung lobe morphology / MGI
small lung lobe / MGI
abnormal branching involved in lung morphogenesis / MGI
impaired branching involved in terminal bronchiole morphogenesis / MGI
abnormal outer hair cell kinocilium morphology / MGI
perinatal lethality, complete penetrance / MGI
prenatal lethality, incomplete penetrance / MGI
thick lung-associated mesenchyme / MGI
increased or absent threshold for auditory brainstem response / MGI

Literature references

A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouse.;Nolan P M, Peters J, Strivens M, Rogers D, Hagan J, Spurr N, Gray I C, Vizor L, Brooker D, Whitehill E, Washbourne R, Hough T, Greenaway S, Hewitt M, Liu X, McCormack S, Pickford K, Selley R, Wells C, Tymowska-Lalanne Z, Roby P, Glenister P, Thornton C, Thaung C, Stevenson J A, Arkell R, Mburu P, Hardisty R, Kiernan A, Erven A, Steel K P, Voegeling S, Guenet J L, Nickols C, Sadri R, Nasse M, Isaacs A, Davies K, Browne M, Fisher E M, Martin J, Rastan S, Brown S D, Hunter J, ;2000;Nature genetics;25;440-3; 10932191

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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C3H.Cg-Celsr1Scy/H