IMPC phenotypes (gene matching)
STOCK Map3k7tm1.1Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:08404 |
| Citation information | RRID:IMSR_EM:08404 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Map3k7tm1.1Gkl/Flmg |
| Alternative name | TAK1FL/FL [B6-Map3k7tm1.1Gkl/Flmg] |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Map3k7tm1.1Gkl |
| Gene/Transgene symbol | Map3k7 |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Al. Fleming |
| Genetic information | A targeting vector was constructed in which a 0.6 kb fragment of Map3k7 containing exon 2 was flanked by loxP sites. The targeting vector also contained an FRT-neo-FRT selection cassette next to the first loxP site and before exon 2. |
| Phenotypic information | Homozygous:No overt phenotype.Heterozygous:No overt phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous C57BL/6J males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Cardiospondylocarpofacial syndrome / Orphanet_3238
- Frontometaphyseal dysplasia / Orphanet_1826
MGI phenotypes (gene matching)
- abnormal vascular development / MGI
- abnormal heart morphology / MGI
- abnormal vascular regression / MGI
- microcephaly / MGI
- short tail / MGI
- open neural tube / MGI
- wavy neural tube / MGI
- abnormal blood vessel morphology / MGI
- decreased embryo size / MGI
- edema / MGI
- pericardial edema / MGI
- hemorrhage / MGI
- small heart / MGI
- abnormal myocardial trabeculae morphology / MGI
- abnormal pharyngeal arch artery morphology / MGI
- abnormal vitelline vasculature morphology / MGI
- thin myocardium compact layer / MGI
- abnormal vitelline vascular remodeling / MGI
- abnormal dorsal aorta morphology / MGI
- abnormal vascular smooth muscle morphology / MGI
- prenatal lethality, complete penetrance / MGI
- embryonic lethality during organogenesis, complete penetrance / MGI
- absent fibroblast proliferation / MGI
- embryo tissue necrosis / MGI
Literature references
- Myeloid TAKI [corrected] acts as a negative regulator of the LPS response and mediates resistance to endotoxemia.;Eftychi Christina, Karagianni Niki, Alexiou Maria, Apostolaki Maria, Kollias George, ;2012;PloS one;7;e31550; 22348103
- Inactivation of the deubiquitinase CYLD in hepatocytes causes apoptosis, inflammation, fibrosis, and cancer.;Nikolaou Kostas, Tsagaratou Ageliki, Eftychi Christina, Kollias George, Mosialos George, Talianidis Iannis, ;2012;Cancer cell;21;738-50; 22698400
- Ubiquitin-specific peptidase 18 negatively regulates and inhibits lipopolysaccharide-induced sepsis by targeting transforming growth factor-β-activated kinase 1 activity.;Hu Bin, Ge Chunhua, Zhu Chunqing, ;2021;International immunology;33;461-468; 34423815