B10;CBA-Tg(CAG-LARGE)126Fmu/H

Status	Available to order
EMMA ID	EM:08668
Citation information	RRID:IMSR_EM:08668 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B10;CBA-Tg(CAG-LARGE)126Fmu/H
Alternative name	LV5 transgenic
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(CAG-LARGE)126Fmu
Gene/Transgene symbol	Tg(CAG-LARGE)126Fmu

Information from provider

Provider	Susan Brown
Provider affiliation	BSU, Mrs Lynn Dorsett
Genetic information	Mice containing LARGE transgene under control of CAAGs promoter.
Phenotypic information	Homozygous: No detectable differences Heterozygous: No detectable differences
References	Transgenic overexpression of LARGE induces α-dystroglycan hyperglycosylation in skeletal and cardiac muscle.;Brockington Martin, Torelli Silvia, Sharp Paul S, Liu Ke, Cirak Sebahattin, Brown Susan C, Wells Dominic J, Muntoni Francesco, ;2010;PloS one;5;e14434; 21203384 The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice.;Whitmore Charlotte, Fernandez-Fuente Marta, Booler Helen, Parr Callum, Kavishwar Manoli, Ashraf Attia, Lacey Erica, Kim Jihee, Terry Rebecca, Ackroyd Mark R, Wells Kim E, Muntoni Francesco, Wells Dominic J, Brown Susan C, ;2014;Human molecular genetics;23;1842-55; 24234655
Homozygous fertile	not known
Homozygous viable	yes
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

Transgenic overexpression of LARGE induces α-dystroglycan hyperglycosylation in skeletal and cardiac muscle.;Brockington Martin, Torelli Silvia, Sharp Paul S, Liu Ke, Cirak Sebahattin, Brown Susan C, Wells Dominic J, Muntoni Francesco, ;2010;PloS one;5;e14434; 21203384
The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice.;Whitmore Charlotte, Fernandez-Fuente Marta, Booler Helen, Parr Callum, Kavishwar Manoli, Ashraf Attia, Lacey Erica, Kim Jihee, Terry Rebecca, Ackroyd Mark R, Wells Kim E, Muntoni Francesco, Wells Dominic J, Brown Susan C, ;2014;Human molecular genetics;23;1842-55; 24234655

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Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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