B6;CBACa-Tg(ADCYAP1R1)1Sshe/H

Status	Available to order
EMMA ID	EM:08840
Citation information	RRID:IMSR_EM:08840 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6;CBACa-Tg(ADCYAP1R1)1Sshe/H
Alternative name	A149
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(ADCYAP1R1)1Sshe
Gene/Transgene symbol	Tg(ADCYAP1R1)1Sshe

Information from provider

Provider	Sanbing Shen
Provider affiliation	School of Medicine, NUI Galway
Genetic information	Transgenic mice carrying 130kb PAC clone 204D22 encoding human ADCYAP1R1 transgene modified with insertion of the IRES-lacZ downstream of the PAC1 receptor coding sequence. Clone A149 is a high expresser (Tg1 in publication PMID:16823490), with a striking hydrocephalus related phenotype
Phenotypic information	Homozygous: High rate of early postnatal death. Transgene-dose dependent hydrocephalus and/or schizophrenia like neuropathology Heterozygous: Transgene-dose dependent hydrocephalus and/or schizophrenia like neuropathology
Breeding history	Littermate mating
References	Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice.;Lang Bing, Song Bing, Davidson Wendy, MacKenzie Alastair, Smith Norman, McCaig Colin D, Harmar Anthony J, Shen Sanbing, ;2006;The Journal of clinical investigation;116;1924-34; 16823490 GABAergic amacrine cells and visual function are reduced in PAC1 transgenic mice.;Lang Bing, Zhao Lei, Cai Li, McKie Lisa, Forrester John V, McCaig Colin D, Jackson Ian J, Shen Sanbing, ;2010;Neuropharmacology;58;215-25; 19596361 Neuropeptide signaling and hydrocephalus: SCO with the flow.;Picketts David J, ;2006;The Journal of clinical investigation;116;1828-32; 16823482
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Literature references

Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice.;Lang Bing, Song Bing, Davidson Wendy, MacKenzie Alastair, Smith Norman, McCaig Colin D, Harmar Anthony J, Shen Sanbing, ;2006;The Journal of clinical investigation;116;1924-34; 16823490
GABAergic amacrine cells and visual function are reduced in PAC1 transgenic mice.;Lang Bing, Zhao Lei, Cai Li, McKie Lisa, Forrester John V, McCaig Colin D, Jackson Ian J, Shen Sanbing, ;2010;Neuropharmacology;58;215-25; 19596361
Neuropeptide signaling and hydrocephalus: SCO with the flow.;Picketts David J, ;2006;The Journal of clinical investigation;116;1828-32; 16823482

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Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
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