B6;CBACa-Tg(ADCYAP1R1)3Sshe/H
| Status | Available to order |
| EMMA ID | EM:08842 |
| Citation information | RRID:IMSR_EM:08842 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;CBACa-Tg(ADCYAP1R1)3Sshe/H |
| Alternative name | A162.6 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(ADCYAP1R1)3Sshe |
| Gene/Transgene symbol | Tg(ADCYAP1R1)3Sshe |
Information from provider
| Provider | Sanbing Shen |
| Provider affiliation | School of Medicine, NUI Galway |
| Genetic information | Transgenic mice carrying 130kb PAC clone 204D22 encoding human ADCYAP1R1 transgene modified with insertion of the IRES-lacZ downstream of the PAC1 receptor coding sequence. Clone A162.6 is a low expresser (Tg3 in publication PMID:16823490), with a mild hydrocephalus related phenotype. |
| Phenotypic information | Homozygous:High rate of early postnatal death. Transgene-dose dependent hydrocephalus and/or schizophrenia like neuropathology.Heterozygous:Transgene-dose dependent hydrocephalus and/or schizophrenia like neuropathology |
| Breeding history | Littermate mating |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Literature references
- Expression of the human PAC1 receptor leads to dose-dependent hydrocephalus-related abnormalities in mice.;Lang Bing, Song Bing, Davidson Wendy, MacKenzie Alastair, Smith Norman, McCaig Colin D, Harmar Anthony J, Shen Sanbing, ;2006;The Journal of clinical investigation;116;1924-34; 16823490
- GABAergic amacrine cells and visual function are reduced in PAC1 transgenic mice.;Lang Bing, Zhao Lei, Cai Li, McKie Lisa, Forrester John V, McCaig Colin D, Jackson Ian J, Shen Sanbing, ;2010;Neuropharmacology;58;215-25; 19596361
- Neuropeptide signaling and hydrocephalus: SCO with the flow.;Picketts David J, ;2006;The Journal of clinical investigation;116;1828-32; 16823482