- preweaning lethality, complete penetrance / IMPC
- embryonic lethality prior to organogenesis / IMPC
- abnormal heart morphology / IMPC
- increased circulating aspartate transaminase level / IMPC
- increased circulating alanine transaminase level / IMPC
- increased heart atrium size / IMPC
- embryonic lethality prior to tooth bud stage / IMPC
- increased heart weight / IMPC
C3HeB/FeJ-Cox15m1Mhda/Ieg
| Status | Available to order |
| EMMA ID | EM:08901 |
| Citation information | RRID:IMSR_EM:08901 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3HeB/FeJ-Cox15m1Mhda/Ieg |
| Alternative name | C3HeB/FeJ-Cox15V187F; internal lab code Cox-01 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Cox15m1Mhda |
| Gene/Transgene symbol | Cox15 |
Information from provider
| Provider | Martin Hrabe de Angelis |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum München |
| Genetic information | Missense point mutation c.559G->T, p.V187F. |
| Phenotypic information | Homozygous:No obvious phenotype observed.Heterozygous:No obvious phenotype observed. |
| Breeding history | Pure C3HeB/FeJ background. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Leigh syndrome with leukodystrophy / Orphanet_255241
- Fatal infantile cytochrome C oxidase deficiency / Orphanet_1561
IMPC phenotypes (gene matching)
Information on how we integrate external resources can be found here
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