C3HeB/FeJ-Cacna2d2m1Mhda/Ieg

Status

Available to order

EMMA IDEM:08902
Citation informationRRID:IMSR_EM:08902 

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International strain nameC3HeB/FeJ-Cacna2d2m1Mhda/Ieg
Alternative nameC3HeB/FeJ-Cacna2d2D780AMhda
Strain typeInduced Mutant Strains : Chemically-induced
Allele/Transgene symbolCacna2d2m1Mhda
Gene/Transgene symbolCacna2d2

Information from provider

ProviderMartin Hrabe de Angelis
Provider affiliationInstitute of Experimental Genetics, Helmholtz Zentrum München
Genetic informationMissense point mutation c.2339A>C, p.D780A; internal lab code Cac-01.
Phenotypic informationHomozygous:
No obvious phenotype observed.

Heterozygous:
No obvious phenotype observed.
Breeding historyPure C3HeB/FeJ background.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreHelmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany

Disease and phenotype information

IMPC phenotypes (gene matching)
  • abnormal kidney morphology / IMPC
  • abnormal testis morphology / IMPC
  • small seminal vesicle / IMPC
  • abnormal spleen morphology / IMPC
  • small kidney / IMPC
  • tremors / IMPC
  • abnormal skin morphology / IMPC
  • small heart / IMPC
  • enlarged spleen / IMPC
  • increased lean body mass / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • no spontaneous movement / IMPC
  • persistence of hyaloid vascular system / IMPC
  • enlarged kidney / IMPC
  • abnormal gait / IMPC
  • abnormal vitreous body morphology / IMPC
  • cataract / IMPC
  • abnormal placenta morphology / IMPC
  • female infertility / IMPC
  • increased spleen weight / IMPC
  • abnormal heart morphology / IMPC
  • enlarged testis / IMPC
  • decreased total body fat amount / IMPC
  • abnormal seminal vesicle morphology / IMPC
  • small spleen / IMPC
MGI phenotypes (gene matching)
  • myoclonus / MGI
  • abnormal pituitary gland morphology / MGI
  • tremors / MGI
  • hindlimb paralysis / MGI
  • abnormal hindbrain morphology / MGI
  • abnormal medulla oblongata morphology / MGI
  • abnormal cerebellum morphology / MGI
  • small cerebellum / MGI
  • cerebellum vermis hypoplasia / MGI
  • Purkinje cell degeneration / MGI
  • abnormal Purkinje cell morphology / MGI
  • decreased Purkinje cell number / MGI
  • abnormal myelination / MGI
  • abnormal motor neuron morphology / MGI
  • abnormal CNS glial cell morphology / MGI
  • abnormal spinal cord morphology / MGI
  • decreased spinal cord size / MGI
  • abnormal neuromuscular synapse morphology / MGI
  • abnormal spinal nerve morphology / MGI
  • abnormal uterus morphology / MGI
  • absent corpus luteum / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal stationary movement / MGI
  • abnormal locomotor behavior / MGI
  • ataxia / MGI
  • impaired coordination / MGI
  • abnormal gait / MGI
  • dehydration / MGI
  • abnormal eating behavior / MGI
  • limb grasping / MGI
  • abnormal motor coordination/balance / MGI
  • abnormal heart rate / MGI
  • postnatal growth retardation / MGI
  • thymus hypoplasia / MGI
  • abnormal thymus involution / MGI
  • rhinitis / MGI
  • reduced fertility / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • female infertility / MGI
  • seizures / MGI
  • abnormal motor capabilities/coordination/movement / MGI
  • premature death / MGI
  • no abnormal phenotype detected / MGI
  • decreased brain weight / MGI
  • abnormal CNS synaptic transmission / MGI
  • abnormal nervous system electrophysiology / MGI
  • abnormal sexual interaction / MGI
  • tonic seizures / MGI
  • abnormal neuron morphology / MGI
  • increased susceptibility to pharmacologically induced seizures / MGI
  • absence seizures / MGI
  • axonal dystrophy / MGI
  • abnormal involuntary movement / MGI
  • nervous system phenotype / MGI
  • abnormal glial cell physiology / MGI
  • decreased neurotransmitter release / MGI
  • abnormal ventral spinal root morphology / MGI
  • abnormal dorsal spinal root morphology / MGI
  • abnormal vertebral column morphology / MGI
  • short vertebral body / MGI
  • abnormal neuron physiology / MGI
  • abnormal miniature endplate potential / MGI
  • abnormal brain wave pattern / MGI
  • lethargy / MGI
  • decreased heart rate / MGI
  • endocrine/exocrine gland phenotype / MGI
  • reproductive system phenotype / MGI
  • abnormal axon morphology / MGI
  • abnormal enzyme/coenzyme activity / MGI
  • abnormal hindbrain development / MGI
  • abnormal spinal cord white matter morphology / MGI
  • behavioral arrest / MGI
  • absent lactotrophs / MGI
  • decreased survivor rate / MGI
  • abnormal spike wave discharge / MGI
  • induced hyperactivity / MGI
  • decreased neuron number / MGI
  • abnormal miniature inhibitory postsynaptic currents / MGI
  • skeletal muscle hypoplasia / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • decreased pons size / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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Legally binding conditions for the transfer

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