IMPC phenotypes (gene matching)
C3HeB/FeJ-Slc2a2m1Mhda/Ieg
| Status | Available to order |
| EMMA ID | EM:08903 |
| Citation information | RRID:IMSR_EM:08903 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C3HeB/FeJ-Slc2a2m1Mhda/Ieg |
| Alternative name | C3HeBFeJ-Slc2a2Splice+GC->ACMhdA |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Slc2a2m1Mhda |
| Gene/Transgene symbol | Slc2a2 |
Information from provider
| Provider | Martin Hrabe de Angelis |
| Provider affiliation | Institute of Experimental Genetics, Helmholtz Zentrum München |
| Genetic information | Splice site mutation exon 2 +GC->AC; internal lab code Slc2-01. |
| Phenotypic information | Homozygous:Homozygous male mice appear perinatal lethal; some but not all homozygous female mice reach weaning age; surviving mice very small, dehydrated appearance.Heterozygous:No obvious phenotype observed. |
| Breeding history | Pure C3HeB/FeJ background. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | females only |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Fanconi-Bickel syndrome / Orphanet_2088
MGI phenotypes (gene matching)
- decreased body weight / MGI
- hyperglycemia / MGI
- abnormal glucose homeostasis / MGI
- abnormal lipid homeostasis / MGI
- increased circulating glucagon level / MGI
- decreased circulating insulin level / MGI
- abnormal pancreatic islet morphology / MGI
- increased fatty acid level / MGI
- abnormal glucose tolerance / MGI
- increased blood osmolality / MGI
- decreased pancreas weight / MGI
- decreased pancreatic beta cell mass / MGI
- postnatal lethality, complete penetrance / MGI
- increased pancreatic alpha cell mass / MGI