B6;CBA-Tg(TNFRSF1B)1335Gkl/Flmg
| Status | Available to order |
| EMMA ID | EM:09003 |
| Citation information | RRID:IMSR_EM:09003 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;CBA-Tg(TNFRSF1B)1335Gkl/Flmg |
| Alternative name | CBA.B6-Tg(TNFRSF1B)1335Gkl/Flmg |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(TNFRSF1B)1335Gkl |
| Gene/Transgene symbol | Tg(TNFRSF1B)1335Gkl |
Information from provider
| Provider | George Kollias |
| Provider affiliation | BSRC Al. Fleming |
| Genetic information | The Tg1335 mice contain as transgene a 70 kb DNA fragment comprising the entire human TNFR2 (TNFRSF1B) genomic sequence. |
| Phenotypic information | Homozygous:Homozygous mice develop a severe pathology characterized by multi-organ inflammation, reduced weight gain, runting, lethargy, and premature lethality.Heterozygous:Heterozygous TgE1335 mice overexpress human TNFR2 (TNFRSF1B) in a physiologically relevant pattern and develop a chronic but mild peri-vascular inflammatory pathology in liver, pancreas, and lung at 2-3 months. |
| References |
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| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | heterozygous CBA x C57BL/6 males |
Literature references
- A critical role of the p75 tumor necrosis factor receptor (p75TNF-R) in organ inflammation independent of TNF, lymphotoxin alpha, or the p55TNF-R.;Douni E, Kollias G, ;1998;The Journal of experimental medicine;188;1343-52; 9763613