B6.Cg-Dnajc11^m1Edou/Flmg

Status	Available to order
EMMA ID	EM:09005
Citation information	RRID:IMSR_EM:09005 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.Cg-Dnajc11^m1Edou/Flmg
Alternative name	B6-DnaJC11/Flmg
Strain type	Induced Mutant Strains : Chemically-induced
Allele/Transgene symbol	Dnajc11^spc
Gene/Transgene symbol	Dnajc11

Information from provider

Provider	Eleni Douni
Provider affiliation	BSRC Al. Fleming
Genetic information	DnaJC spc/spc mice carry a hypomorphic mutation in the Dnajc11 gene caused by an intronic T to A transition. This point mutation generated a new splice acceptor site leading to the incorporation of the 109 bp intronic sequence into the mature transcript of 63 kDa isoform of the Dnajc11 gene product. This insertion changed the reading frame and was predicted to result in the replacement of the 51 C-terminal amino acids of the protein by 43 different ones.
Phenotypic information	Homozygous: Homozygous mutants develop an autosomal recessive neuromuscular pathology characterized by locomotion defects, muscle weakness, spasticity, limb tremor, leucopenia, thymic and splenic hypoplasia, general wasting and early lethality. Heterozygous: No overt phenotype
References	A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice.;Ioakeimidis Fotis, Ott Christine, Kozjak-Pavlovic Vera, Violitzi Foteini, Rinotas Vagelis, Makrinou Eleni, Eliopoulos Elias, Fasseas Costas, Kollias George, Douni Eleni, ;2014;PloS one;9;e104237; 25111180
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	not known

Information from EMMA

Archiving centre	B.S.R.C. Alexander Fleming, Vari, Greece
Animals used for archiving	heterozygous C57BL/6J males

Disease and phenotype information

MGI phenotypes (gene matching)

decreased leukocyte cell number / MGI
spleen hypoplasia / MGI
tremors / MGI
progressive muscle weakness / MGI
abnormal motor neuron morphology / MGI
abnormal locomotor behavior / MGI
limb grasping / MGI
postnatal growth retardation / MGI
thymus hypoplasia / MGI
premature death / MGI
decreased erythrocyte cell number / MGI
abnormal limb posture / MGI
decreased thymus weight / MGI
decreased B cell number / MGI
increased double-negative T cell number / MGI
decreased double-positive T cell number / MGI
cachexia / MGI
hematopoietic system phenotype / MGI
brain vacuoles / MGI
increased CD4-positive, alpha beta T cell number / MGI
increased CD8-positive, alpha-beta T cell number / MGI
increased DN1 thymic pro-T cell number / MGI
disorganized mitochondrial cristae / MGI
spasticity / MGI
thymus cortex atrophy / MGI
enlarged thymus medulla / MGI

Literature references

A splicing mutation in the novel mitochondrial protein DNAJC11 causes motor neuron pathology associated with cristae disorganization, and lymphoid abnormalities in mice.;Ioakeimidis Fotis, Ott Christine, Kozjak-Pavlovic Vera, Violitzi Foteini, Rinotas Vagelis, Makrinou Eleni, Eliopoulos Elias, Fasseas Costas, Kollias George, Douni Eleni, ;2014;PloS one;9;e104237; 25111180

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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B6.Cg-Dnajc11m1Edou/Flmg