- arrested T cell differentiation / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal B cell morphology / MGI
- abnormal regulatory T cell physiology / MGI
- absent T cells / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- absent CD4-positive, alpha beta T cells / MGI
B6.Cg-Ptprca Cd3etm1Mal/Orl
| Status | Available to order |
| EMMA ID | EM:09059 |
| Citation information | RRID:IMSR_EM:09059 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Ptprca Cd3etm1Mal/Orl |
| Alternative name | C57bl/6-CD3 Epsilon KO Ly5.1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Cd3etm1Mal, Ptprca |
| Gene/Transgene symbol | Cd3e, Ptprc |
Information from provider
| Provider | Benedita Rocha |
| Provider affiliation | INSERM U 1020, INSERM |
| Genetic information | Knock-out for the Cd3e gene: insertion of neo cassette into exon 5 of Cd3e. |
| Phenotypic information | Homozygous:Mice have all the cells without CD3e and expressing Ptprc-a (Ly5.1).Heterozygous:Mice have 50% cells expressing CD3e and Ptprc-a (Ly5.1). |
| Breeding history | Currently bred as homozygous Cd3e knock-out and C57BL/6 Ptprca (Ly5.1). |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | yes |
Information from EMMA
| Archiving centre | CNRS-TAAM – Typing and Archiving of Animal Models, Orléans, France |
| Animals used for archiving | homozygous C57BL/6J males, homozygous C57BL/6J females |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- T-B+ severe combined immunodeficiency due to CD45 deficiency / Orphanet_169157
- T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta / Orphanet_169160
MGI phenotypes (allele matching)
MGI phenotypes (gene matching)
- abnormal thymus morphology / MGI
- small thymus / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- seizures / MGI
- abnormal T cell differentiation / MGI
- abnormal double-negative T cell morphology / MGI
- abnormal double-positive T cell morphology / MGI
- absent CD4-positive, alpha beta T cells / MGI
- abnormal class switch recombination / MGI
- abnormal B cell morphology / MGI
- abnormal regulatory T cell physiology / MGI
- increased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- abnormal T cell number / MGI
- increased T cell apoptosis / MGI
- abnormal T cell morphology / MGI
- absent T cells / MGI
- increased sensitivity to induced morbidity/mortality / MGI
- increased DN3 thymocyte number / MGI
- abnormal long bone metaphysis morphology / MGI
- abnormal leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- decreased leukocyte cell number / MGI
- extramedullary hematopoiesis / MGI
- abnormal erythropoiesis / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- enlarged lymph nodes / MGI
- decreased thymocyte number / MGI
- abnormal immune system cell morphology / MGI
- abnormal myelination / MGI
- abnormal oligodendrocyte morphology / MGI
- abnormal osteoclast physiology / MGI
- abnormal digestion / MGI
- abnormal immune system physiology / MGI
- abnormal humoral immune response / MGI
- thymus hypoplasia / MGI
- arrested T cell differentiation / MGI
- abnormal T cell activation / MGI
- liver inflammation / MGI
- lung inflammation / MGI
- premature death / MGI
- abnormal T cell differentiation / MGI
- no abnormal phenotype detected / MGI
- abnormal bone marrow cell morphology/development / MGI
- abnormal lymphopoiesis / MGI
- abnormal double-positive T cell morphology / MGI
- increased susceptibility to viral infection / MGI
- abnormal T cell physiology / MGI
- abnormal B cell number / MGI
- increased IgA level / MGI
- abnormal immune system organ morphology / MGI
- glomerulonephritis / MGI
- increased urine protein level / MGI
- abnormal cytokine secretion / MGI
- no phenotypic analysis / MGI
- kidney failure / MGI
- oliguria / MGI
- abnormal thymocyte activation / MGI
- abnormal T cell subpopulation ratio / MGI
- increased anti-double stranded DNA antibody level / MGI
- abnormal T cell selection / MGI
- abnormal positive T cell selection / MGI
- increased B-1 B cell number / MGI
- abnormal osteoclast morphology / MGI
- increased B cell number / MGI
- increased T cell number / MGI
- decreased B cell number / MGI
- decreased T cell number / MGI
- abnormal response to infection / MGI
- diarrhea / MGI
- decreased cytotoxic T cell cytolysis / MGI
- increased double-negative T cell number / MGI
- decreased double-positive T cell number / MGI
- decreased B cell proliferation / MGI
- decreased T cell proliferation / MGI
- increased susceptibility to autoimmune disorder / MGI
- immune system phenotype / MGI
- hematopoietic system phenotype / MGI
- decreased susceptibility to type I hypersensitivity reaction / MGI
- CNS inflammation / MGI
- increased T cell apoptosis / MGI
- abnormal T cell morphology / MGI
- increased NK cell number / MGI
- abnormal memory T cell number / MGI
- increased memory T cell number / MGI
- decreased memory T cell number / MGI
- absent T cells / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- abnormal CD4-positive T cell differentiation / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- abnormal CD8-positive, alpha-beta T cell differentiation / MGI
- increased single-positive T cell number / MGI
- decreased single-positive T cell number / MGI
- increased plasma cell number / MGI
- lymph node hyperplasia / MGI
- abnormal granulocyte differentiation / MGI
- increased dendritic cell number / MGI
- decreased B-1a cell number / MGI
- increased B-1b cell number / MGI
- decreased B-1b cell number / MGI
- decreased follicular B cell number / MGI
- increased transitional stage B cell number / MGI
- abnormal follicular B cell physiology / MGI
- decreased B-2 B cell number / MGI
- decreased mature B cell number / MGI
- abnormal B cell activation / MGI
- abnormal leukocyte morphology / MGI
- decreased gamma-delta intraepithelial T cell number / MGI
- abnormal CD4-positive, alpha-beta intraepithelial T cell morphology / MGI
- increased spleen red pulp amount / MGI
- increased spleen white pulp amount / MGI
- increased IgG2a level / MGI
- increased plasmacytoid dendritic cell number / MGI
- abnormal chemokine secretion / MGI
- decreased memory B cell number / MGI
- decreased mast cell degranulation / MGI
- abnormal intraepithelial T cell morphology / MGI
- abnormal intraepithelial T cell number / MGI
- decreased oligodendrocyte number / MGI
- increased DN3 thymocyte number / MGI
- decreased DN4 thymocyte number / MGI
- abnormal NK cell physiology / MGI
- mortality/aging / MGI
- decreased CD4-positive, alpha-beta memory T cell number / MGI
- decreased CD8-positive, alpha-beta memory T cell number / MGI
- lethality at weaning, incomplete penetrance / MGI
- increased alpha-beta T cell number / MGI
- decreased CD8-positive, naive alpha-beta T cell number / MGI
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