IMPC phenotypes (gene matching)
B6.129-Grin1tm1Rsp/Kctt
| Status | Available to order |
| EMMA ID | EM:09220 |
| Citation information | RRID:IMSR_EM:09220 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Grin1tm1Rsp/Kctt |
| Alternative name | Grin1-2lox/Rsp (lab name NR1-2lox) |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Grin1tm1Rsp |
| Gene/Transgene symbol | Grin1 |
Information from provider
| Provider | Rolf Sprengel |
| Provider affiliation | Molecular Neurobiology, Max Planck Institute for Medical Research |
| Genetic information | Mice with (loxP5171) (Lee & Saito, 1998) flanking the gene for the principal NMDA receptor subunit GluN1 (Grin1 gene; exons 11–18) were generated by gene targeting in embryonic stem cells. No selection marker is present and two loxP sites are flanking part of the Grin1 gene. |
| Phenotypic information | Homozygous:No PhenotypeHeterozygous:No Phenotype |
| Breeding history | Embryos from 2013. Line was generated 2000 |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | homozygous C57BL/6 males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal dominant non-syndromic intellectual disability / Orphanet_178469
- Bilateral generalized polymicrogyria / Orphanet_208447
- Early infantile epileptic encephalopathy / Orphanet_1934
MGI phenotypes (gene matching)
- abnormal trigeminal nerve morphology / MGI
- atelectasis / MGI
- lung hemorrhage / MGI
- overexpanded pulmonary alveoli / MGI
- decreased body weight / MGI
- abnormal social investigation / MGI
- social withdrawal / MGI
- abnormal anxiety-related response / MGI
- reduced male mating frequency / MGI
- abnormal pup retrieval / MGI
- pup cannibalization / MGI
- abnormal maternal nurturing / MGI
- abnormal locomotor behavior / MGI
- ataxia / MGI
- hyperactivity / MGI
- hypoactivity / MGI
- impaired coordination / MGI
- stereotypic behavior / MGI
- increased exploration in new environment / MGI
- absent suckling reflex / MGI
- abnormal suckling behavior / MGI
- aphagia / MGI
- abnormal nest building behavior / MGI
- abnormal huddling behavior / MGI
- abnormal spatial learning / MGI
- reduced long term potentiation / MGI
- increased startle reflex / MGI
- impaired righting response / MGI
- cyanosis / MGI
- postnatal growth retardation / MGI
- absence of NMDA-mediated synaptic currents / MGI
- reduced male fertility / MGI
- abnormal respiration / MGI
- abnormal breathing pattern / MGI
- respiratory distress / MGI
- apnea / MGI
- abnormal motor capabilities/coordination/movement / MGI
- premature death / MGI
- no abnormal phenotype detected / MGI
- abnormal nervous system electrophysiology / MGI
- abnormal social/conspecific interaction / MGI
- decreased vertical activity / MGI
- abnormal conditioned taste aversion behavior / MGI
- abnormal glutamate-mediated receptor currents / MGI
- decreased susceptibility to pharmacologically induced seizures / MGI
- abnormal NMDA-mediated synaptic currents / MGI
- no phenotypic analysis / MGI
- thrombocytopenia / MGI
- increased alcohol consumption / MGI
- decreased alcohol consumption / MGI
- nervous system phenotype / MGI
- abnormal nervous system physiology / MGI
- decreased aggression towards mice / MGI
- impaired passive avoidance behavior / MGI
- abnormal miniature excitatory postsynaptic currents / MGI
- abnormal neuron physiology / MGI
- abnormal brainstem morphology / MGI
- cardiovascular system phenotype / MGI
- behavior/neurological phenotype / MGI
- taste/olfaction phenotype / MGI
- abnormal food intake / MGI
- abnormal pulmonary respiratory rate / MGI
- decreased susceptibility to neuronal excitotoxicity / MGI
- abnormal physiological response to xenobiotic / MGI
- decreased prepulse inhibition / MGI
- abnormal maternal grooming / MGI
- absent gastric milk in neonates / MGI
- abnormal behavioral response to xenobiotic / MGI
- reduced AMPA-mediated synaptic currents / MGI
- postnatal lethality, complete penetrance / MGI
- postnatal lethality, incomplete penetrance / MGI
- neonatal lethality, complete penetrance / MGI
- perinatal lethality, complete penetrance / MGI
- perinatal lethality, incomplete penetrance / MGI
- abnormal behavioral response to alcohol / MGI
Literature references
- Impaired spatial working memory but spared spatial reference memory following functional loss of NMDA receptors in the dentate gyrus.;Niewoehner B, Single F N, Hvalby Ø, Jensen V, Meyer zum Alten Borgloh S, Seeburg P H, Rawlins J N P, Sprengel R, Bannerman D M, ;2007;The European journal of neuroscience;25;837-46; 17313573
- Dissecting spatial knowledge from spatial choice by hippocampal NMDA receptor deletion.;Bannerman David M, Bus Thorsten, Taylor Amy, Sanderson David J, Schwarz Inna, Jensen Vidar, Hvalby Øivind, Rawlins J Nicholas P, Seeburg Peter H, Sprengel Rolf, ;2012;Nature neuroscience;15;1153-9; 22797694
- Cre-Activation in ErbB4-Positive Neurons of Floxed Grin1/NMDA Receptor Mice Is Not Associated With Major Behavioral Impairment.;Mallien Anne S, Pfeiffer Natascha, Vogt Miriam A, Chourbaji Sabine, Sprengel Rolf, Gass Peter, Inta Dragos, ;2021;Frontiers in psychiatry;12;750106; 34899420
- Age-Dependent Degeneration of Mature Dentate Gyrus Granule Cells Following NMDA Receptor Ablation.;Watanabe Yasuhito, Müller Michaela K, von Engelhardt Jakob, Sprengel Rolf, Seeburg Peter H, Monyer Hannah, ;2015;Frontiers in molecular neuroscience;8;87; 26793056