MGI phenotypes (allele matching)
B6.129-Col15a1tm1Pih/Oulu
| Status | Available to order |
| EMMA ID | EM:09264 |
| Citation information | RRID:IMSR_EM:09264 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Col15a1tm1Pih/Oulu |
| Alternative name | Collagen XV knock-out mouse in C57BL6 background |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Col15a1tm1Pih |
| Gene/Transgene symbol | Col15a1 |
Information from provider
| Provider | Lauri Eklund |
| Provider affiliation | Faculty of Biochemistry and Molecular Medicine and Biocenter Oulu |
| Additional owner | Prof. Taina Pihlajaniemi, University of Oulu, Oulu, Finland. |
| Genetic information | Col15a1tm1Pih |
| Phenotypic information | Homozygous:Cardiovascular and nerve maturation.Heterozygous:Not observed |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6OlaHsd males |
Disease and phenotype information
Literature references
- Lack of type XV collagen causes a skeletal myopathy and cardiovascular defects in mice.;Eklund L, Piuhola J, Komulainen J, Sormunen R, Ongvarrasopone C, Fássler R, Muona A, Ilves M, Ruskoaho H, Takala T E, Pihlajaniemi T, ;2001;Proceedings of the National Academy of Sciences of the United States of America;98;1194-9; 11158616
- Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy.;Rasi Karolina, Piuhola Jarkko, Czabanka Marcus, Sormunen Raija, Ilves Mika, Leskinen Hanna, Rysä Jaana, Kerkelä Risto, Janmey Paul, Heljasvaara Ritva, Peuhkurinen Keijo, Vuolteenaho Olli, Ruskoaho Heikki, Vajkoczy Peter, Pihlajaniemi Taina, Eklund Lauri, ;2010;Circulation research;107;1241-52; 20847313
- Lack of collagen XV impairs peripheral nerve maturation and, when combined with laminin-411 deficiency, leads to basement membrane abnormalities and sensorimotor dysfunction.;Rasi Karolina, Hurskainen Merja, Kallio Mika, Stavén Saara, Sormunen Raija, Heape Anthony M, Avila Robin L, Kirschner Daniel, Muona Anu, Tolonen Uolevi, Tanila Heikki, Huhtala Pirkko, Soininen Raija, Pihlajaniemi Taina, ;2010;The Journal of neuroscience : the official journal of the Society for Neuroscience;30;14490-501; 20980607