MGI phenotypes (allele matching)
STOCK Setd7tm1.1Ital/Flmg
| Status | Available to order |
| EMMA ID | EM:09467 |
| Citation information | RRID:IMSR_EM:09467 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Setd7tm1.1Ital/Flmg |
| Alternative name | B6.CBA-Setd7 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Setd7tm1.1Ital |
| Gene/Transgene symbol | Setd7 |
Information from provider
| Provider | Iannis Talianidis |
| Provider affiliation | BSRC Alexander Fleming |
| Genetic information | Cre-mediated recombination removed exon 4 of the Setd7 gene from the floxed Setd7tm1Ital allele. |
| Phenotypic information | Homozygous:No overt phenotypeHeterozygous:No overt phenotype |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | B.S.R.C. Alexander Fleming, Vari, Greece |
| Animals used for archiving | homozygous CBA x C57BL/6 males, wild-type (C57BL/6 x CBA)F1 females |
| Stage of embryos | 2-cell |
Disease and phenotype information
MGI phenotypes (gene matching)
- abnormal lung morphology / MGI
- abnormal lung compliance / MGI
- abnormal cell cycle checkpoint function / MGI
- decreased susceptibility to injury / MGI
- abnormal protein level / MGI
- abnormal spleen physiology / MGI
- decreased physiological sensitivity to xenobiotic / MGI
- decreased sensitivity to induced cell death / MGI
- prenatal lethality, incomplete penetrance / MGI
- abnormal extracellular matrix morphology / MGI
Literature references
- SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.;Elkouris Maximilianos, Kontaki Haroula, Stavropoulos Athanasios, Antonoglou Anastasia, Nikolaou Kostas C, Samiotaki Martina, Szantai Eszter, Saviolaki Dimitra, Brown Peter J, Sideras Paschalis, Panayotou George, Talianidis Iannis, ;2016;Cell reports;15;2733-44; 27292644