B6.C3H-Tg(CMV-Cux1)#Gbvh/Biat
| Status | Available to order |
| EMMA ID | EM:09679 |
| Citation information | RRID:IMSR_EM:09679 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.C3H-Tg(CMV-Cux1)#Gbvh/Biat |
| Alternative name | B6.C3H-Tg(CMV-Cux1) |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(CMV-Cux1)#Gbvh |
| Gene/Transgene symbol | Tg(CMV-Cux1)#Gbvh |
Information from provider
| Provider | Gregory Vanden Heuvel |
| Provider affiliation | Department of Biomedical Sciences, Western Michigan University School of Medicine |
| Genetic information | Mice constitutively expressing Cux1 developed multiorgan hyperplasia and organomegaly, but not an overall increase in body size. Transgenic kidneys were enlarged 50% by 6 weeks of age, with the increased growth primarily restricted to the cortex. In the developing kidneys of transgenic mice, Cux1 was ectopically expressed in more highly differentiated tubules and glomeruli, and this was associated with reduced expression of the cyclin kinase inhibitor, p27. |
| Phenotypic information | Homozygous:No data with homozygous mice.Heterozygous:Transgenic mice survived to adulthood and appeared identical to wild-type mice. Adult CMV/Cux1 mice exhibited enlargement of multiple visceral organs, but the average body weight of the transgenic mice was not increased. By 6 weeks of age, the kidney, liver, and spleen were 50-100% larger than in wild-type mice. At 3 and 6 months of age, the kidney, liver, and heart were still proportionally larger in the transgenic mice, but the transgenic spleen was comparable in size to that in the wild-type mice. At all three ages, the testes were slightly larger in the transgenic mice, but as the mice got older, this difference in size was less significant. Also an increased size of the seminal vesicles in the CMV/Cux1 mice observed, as compared with those in the wild-type mice. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Veterinary Medicine, Vienna, Austria |
| Animals used for archiving | heterozygous males |
Literature references
- Deregulated expression of the homeobox gene Cux-1 in transgenic mice results in downregulation of p27(kip1) expression during nephrogenesis, glomerular abnormalities, and multiorgan hyperplasia.;Ledford Aric W, Brantley Jennifer G, Kemeny Gabor, Foreman Tonia L, Quaggin Susan E, Igarashi Peter, Oberhaus Stephanie M, Rodova Marianna, Calvet James P, Vanden Heuvel Gregory B, ;2002;Developmental biology;245;157-71; 11969263
- Hepatomegaly in transgenic mice expressing the homeobox gene Cux-1.;Vanden Heuvel Gregory B, Brantley Jennifer G, Alcalay Neal I, Sharma Madhulika, Kemeny Gabor, Warolin Joshua, Ledford Aric W, Pinson David M, ;2005;Molecular carcinogenesis;43;18-30; 15812824
- Cux-1 transgenic mice develop glomerulosclerosis and interstitial fibrosis.;Brantley Jennifer G, Sharma Madhulika, Alcalay Neal I, Heuvel Gregory B Vanden, ;2003;Kidney international;63;1240-8; 12631340