| Status | Available to order |
| EMMA ID | EM:09689 |
| Citation information | RRID:IMSR_EM:09689 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Ldlrtm1Her Tg(APOB*Q2153L)#Boren/Kctt |
| Alternative name | B6.C57BL/6XSJL-Tg(huB100tm).129S7-Ldlrtm1Her |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(APOB*Q2153L)#Boren, Ldlrtm1Her |
| Gene/Transgene symbol | Tg(APOB*Q2153L)#Boren, Ldlr |
| Provider | Jan Borén |
| Provider affiliation | Molecular and Clinical Medicine, University of Gothenburg |
| Additional owner | Göran Hansson, Daniel Ketelhuth and Alexandra Bäcklund, The Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden |
| Genetic information | These mice carry the full-length human APOB100 gene, in which codon 2153 has been converted from leucine to glutamine to prevent the formation of ApoB48, generating only ApoB100. They are also deficient in LDLr and have an increased level of LDL-cholesterol, VLDL-cholesterol, and low HDL relative to wild-type mice and develop spontaneous atherosclerosis. |
| Phenotypic information | Homozygous:Mice have hypercholesterolemia and develop spontaneous atherosclerotic lesions. Females have an earlier onset with lesions at 18 weeks compared with males (onset at 26 weeks). Mice are healthy and have no visible effect with a normal life span.Heterozygous:Mice have mild hypercholesterolemia but do not develop spontaneous atherosclerotic lesions. Mice are healthy and have no visible effect with a normal life span. |
| Breeding history | Mice were received at 4 generations backcrossed to C57BL/6J. The mice were then crossed a further 6 generations to C57BL/6J, purchased from JAX Mice in USA. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
| Animals used for archiving | homozygous C57BL/6J males |
Orphanet associated rare diseases, based on orthologous gene matching
