IMPC phenotypes (gene matching)
B6;129P2-Chd4tm1.1Bh/H
| Status | Available to order |
| EMMA ID | EM:09714 |
| Citation information | RRID:IMSR_EM:09714 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Chd4tm1.1Bh/H |
| Alternative name | CHD4 Flox |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Chd4tm1.1Bh |
| Gene/Transgene symbol | Chd4 |
Information from provider
| Provider | Brian Hendrich |
| Provider affiliation | Wellcome Trust - MRC Stem Cell Institute, University of Cambridge |
| Genetic information | Conditional allele of Chd4. |
| Phenotypic information | Homozygous:Homozygous floxed has no phenotype. Homozygous deletion is lethal at 3.5 dpc.Heterozygous:Heterozygous floxed or heterozygous deletion has no phenotype. |
| Breeding history | Created from 129/Ola ES cell line, outcrossed to C57BL/6 once, then maintained as sib matings. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
Literature references
- Constraint of gene expression by the chromatin remodelling protein CHD4 facilitates lineage specification.;O'Shaughnessy-Kirwan Aoife, Signolet Jason, Costello Ita, Gharbi Sarah, Hendrich Brian, ;2015;Development (Cambridge, England);142;2586-97; 26116663
- Chd4 choreographs self-antigen expression for central immune tolerance.;Tomofuji Yoshihiko, Takaba Hiroyuki, Suzuki Hiroshi I, Benlaribi Rayene, Martinez Cristian David Peña, Abe Yoshihiro, Morishita Yasuyuki, Okamura Tadashi, Taguchi Akashi, Kodama Tatsuhiko, Takayanagi Hiroshi, ;2020;Nature immunology;21;892-901; 32601470