MGI phenotypes (gene matching)
STOCK Tmprss4tm1.2Hum/Ph
| Status | Available to order |
| EMMA ID | EM:09860 |
| Citation information | RRID:IMSR_EM:09860 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tmprss4tm1.2Hum/Ph |
| Alternative name | Tmprss4 -/- |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tmprss4tm1.2Hum |
| Gene/Transgene symbol | Tmprss4 |
Information from provider
| Provider | Edith Hummler |
| Provider affiliation | Département de Pharmacologie et de Toxicologie, University of Lausanne |
| Genetic information | Homologous recombination in mouse embryonic stem cells was performed to place loxP sites around exons 8 and 9 of the Tmprss4 gene locus containing the histidine and the aspartate of the catalytic triad. Southern blot analyses confirmed correct targeting of ES cell. Tmprss4loxneo/+ mice were mated with Cre- or Flp-deleter mouse strains, and floxed heterozygous mutant and knockout mice were obtained. |
| Phenotypic information | Homozygous:Tmprss4 knockout mice do not show an obvious phenotype and are viable and fertile.Heterozygous:Tmprss4 heterozygous mice do not show an obvious phenotype and are viable and fertile. |
| Breeding history | The line was maintained by crossing Tmprss4 +/- with Tmprss4 +/-. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
| Animals used for archiving | heterozygous males |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive cerebral atrophy / Orphanet_363969
Literature references
- Epithelial Sodium Channel-Mediated Sodium Transport Is Not Dependent on the Membrane-Bound Serine Protease CAP2/Tmprss4.;Keppner Anna, Andreasen Ditte, Mérillat Anne-Marie, Bapst Julie, Ansermet Camille, Wang Qing, Maillard Marc, Malsure Sumedha, Nobile Antoine, Hummler Edith, ;2015;PloS one;10;e0135224; 26309024