C57BL/6-Atm1Brd Mtrfrtm1(KOMP)Mbp/Oulu
| Status | Available to order |
| EMMA ID | EM:09863 |
| Citation information | RRID:IMSR_EM:09863 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6-Atm1Brd Mtrfrtm1(KOMP)Mbp/Oulu |
| Alternative name | 2810006K23Riktm1(KOMP)Mbp |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mtrfrtm1(KOMP)Mbp |
| Gene/Transgene symbol | Mtrfr |
Information from provider
| Provider | Brendan Battersby |
| Provider affiliation | University of Helsinki |
| Genetic information | Reporter-tagged deletion allele (with selection cassette). Generated from ES cell line DEPD00502_6_E10. |
| Phenotypic information | Homozygous:NAHeterozygous:NA |
| Breeding history | Chimeric males were bred with wild-type females to produce heterozygotes. Sperm was isolated and cryopreserved from heterozygous males and quality tested by IVF. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6NCrl;C57BL/6JOlaHsd males, wild-type C57BL/6JOlaHsd females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive spastic paraplegia type 55 / Orphanet_320375
- Combined oxidative phosphorylation defect type 7 / Orphanet_254930
Literature references
- Evaluating the feasibility of gene replacement strategies to treat MTRFR deficiency.;Pratt Samia L, Zarate-Mendez Mariana, Koludarova Lidiia, Jansson Sonja, Airavaara Mikko, Hlushchuk Irena, Coleman David, Heffner Caleb, Horvath Rita, Battersby Brendan J, Burgess Robert W, ;2025;Disease models & mechanisms;18;; 40452409