MGI phenotypes (gene matching)
- no abnormal phenotype detected / MGI
C57BL/6N-Ndnftm1(NCOM)Mfgc/Oulu
| Status | Available to order |
| EMMA ID | EM:09864 |
| Citation information | RRID:IMSR_EM:09864 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Ndnftm1(NCOM)Mfgc/Oulu |
| Alternative name | Ndnftm1(NCOM)Mfgc |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ndnftm1(NCOM)Mfgc |
| Gene/Transgene symbol | Ndnf |
Information from provider
| Provider | Taneli Raivio |
| Provider affiliation | Institute of Biomedicine/Physiology, University of Helsinki |
| Genetic information | The insertion of NorCOMM cassette pGOHANU created a deletion of size 4984 bp between positions 65652593-65657577 of chromosome 6. Generated from ES cell line N02206P1_C_217W_B6. |
| Phenotypic information | Homozygous:NAHeterozygous:NA |
| Breeding history | Chimeric males were bred with wild-type females to obtain heterozygotes. Sperm was isolated and cryopreserved from het males and quality tested by IVF. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | University of Oulu, Oulu, Finland |
| Animals used for archiving | heterozygous C57BL/6N males, wild-type C57BL/6NCrl females |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Kallmann syndrome / Orphanet_478
Literature references
- Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism.;Messina Andrea, Pulli Kristiina, Santini Sara, Acierno James, Känsäkoski Johanna, Cassatella Daniele, Xu Cheng, Casoni Filippo, Malone Samuel A, Ternier Gaetan, Conte Daniele, Sidis Yisrael, Tommiska Johanna, Vaaralahti Kirsi, Dwyer Andrew, Gothilf Yoav, Merlo Giorgio R, Santoni Federico, Niederländer Nicolas J, Giacobini Paolo, Raivio Taneli, Pitteloud Nelly, ;2020;American journal of human genetics;106;58-70; 31883645