IMPC phenotypes (gene matching)
B6.C3Fe-Slc38a3m1Ingm/Ph
| Status | Available to order |
| EMMA ID | EM:09936 |
| Citation information | RRID:IMSR_EM:09936 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.C3Fe-Slc38a3m1Ingm/Ph |
| Alternative name | Snat3 |
| Strain type | Induced Mutant Strains : Chemically-induced |
| Allele/Transgene symbol | Slc38a3m1Ingm |
| Gene/Transgene symbol | Slc38a3 |
Information from provider
| Provider | Carsten A. Wagner |
| Provider affiliation | Institute of Laboratory Animal Science, University of Zurich |
| Genetic information | ENU induced a nucleotide exchange C to T resulting in a premature stop codon (Q263X) deleting the second half of the Snat3 protein. |
| Phenotypic information | Snat3/Slc38a3 mutant mice showed stunted growth, altered amino acid levels in plasma and organs, hypoglycemia, altered ammoniagenesis and died around 20 days after birth. |
| Breeding history | Mice were generated in C3H background and outcrossed for 10 generations to C57BL/6J background. Currently, heterozygous breeding. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institute of Molecular Genetics, Prague, Czech Republic |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
MGI phenotypes (allele matching)
- decreased body weight / MGI
- decreased body size / MGI
- increased circulating carnitine level / MGI
- abnormal circulating amino acid level / MGI
- abnormal amino acid level / MGI
- homeostasis/metabolism phenotype / MGI
- increased blood urea nitrogen level / MGI
- postnatal lethality, complete penetrance / MGI
- increased circulating histidine level / MGI
- decreased urine ammonia level / MGI
- increased circulating homocysteine level / MGI
- decreased circulating tyrosine level / MGI
MGI phenotypes (gene matching)
- decreased body weight / MGI
- decreased body size / MGI
- ataxia / MGI
- decreased circulating insulin level / MGI
- lethargy / MGI
- abnormal circulating amino acid level / MGI
- abnormal amino acid level / MGI
- homeostasis/metabolism phenotype / MGI
- decreased circulating glucose level / MGI
- increased blood urea nitrogen level / MGI
- abnormal insulin-like growth factor I level / MGI
- postnatal lethality, complete penetrance / MGI
- decreased urine urea nitrogen level / MGI
- increased circulating histidine level / MGI
- decreased urine ammonia level / MGI
- increased circulating homocysteine level / MGI
- decreased circulating tyrosine level / MGI
- increased circulating cysteine level / MGI
- decreased circulating alanine level / MGI
- decreased phenylalanine level / MGI
- increased circulating threonine level / MGI
- increased glutamine level / MGI
- decreased glutamine level / MGI
- decreased gamma-aminobutyric acid level / MGI
- decreased glutamic acid level / MGI
- decreased leucine level / MGI
- increased circulating leucine level / MGI
Literature references
- Loss of function mutation of the Slc38a3 glutamine transporter reveals its critical role for amino acid metabolism in the liver, brain, and kidney.;Chan Kessara, Busque Stephanie M, Sailer Manuela, Stoeger Claudia, Bröer Stefan, Daniel Hannelore, Rubio-Aliaga Isabel, Wagner Carsten A, ;2016;Pflugers Archiv : European journal of physiology;468;213-27; 26490457