C57BL/6-Ep300tm1Dsl/H

Status

Available to order

EMMA IDEM:04590
Citation informationRRID:IMSR_EM:04590 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6-Ep300tm1Dsl/H
Alternative namep300 S89A
Strain typeTargeted Mutant Strains : Point mutation
Allele/Transgene symbolEp300tm1Dsl
Gene/Transgene symbolEp300

Information from provider

ProviderDavid Latchman
Provider affiliationWindeyer Institute of Medical Sciences, University College London
Genetic informationPoint mutation of p300: serine 89 to alanine.
Phenotypic informationReduced weight from birth and defects in phenylephrine-induced cardiac hypertrophy
Breeding historyThe ES cells and recipient mouse were both C57BL/6; the line has been maintained for 8 generations on C57BL/6 background
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivinghomozygous C57BL/6 males
Breeding at archiving centreMales were archived as homozygotes on a C57BL/6 background, as supplied by the depositor.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • decreased leukocyte cell number / MGI
  • abnormal heart development / MGI
  • enlarged heart / MGI
  • thin ventricular wall / MGI
  • abnormal heart valve morphology / MGI
  • absent trabeculae carneae / MGI
  • abnormal intestinal epithelium morphology / MGI
  • abnormal small intestine morphology / MGI
  • decreased thymocyte number / MGI
  • abnormal myogenesis / MGI
  • exencephaly / MGI
  • open neural tube / MGI
  • abnormal lung development / MGI
  • decreased body size / MGI
  • microphthalmia / MGI
  • cyanosis / MGI
  • anemia / MGI
  • abnormal vasculogenesis / MGI
  • internal hemorrhage / MGI
  • incomplete somite formation / MGI
  • decreased embryo size / MGI
  • incomplete embryo turning / MGI
  • embryonic growth arrest / MGI
  • edema / MGI
  • hemorrhage / MGI
  • respiratory failure / MGI
  • neoplasm / MGI
  • postnatal lethality / MGI
  • abnormal muscle morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal erythrocyte morphology / MGI
  • anisocytosis / MGI
  • thin myocardium / MGI
  • abnormal epicardium morphology / MGI
  • abnormal vitelline vasculature morphology / MGI
  • kinked neural tube / MGI
  • abnormal facial morphology / MGI
  • embryonic growth retardation / MGI
  • abnormal muscle fiber morphology / MGI
  • decreased eosinophil cell number / MGI
  • decreased lymphocyte cell number / MGI
  • decreased B cell number / MGI
  • decreased cardiac muscle contractility / MGI
  • pericardial effusion / MGI
  • hematopoietic system phenotype / MGI
  • thrombocytosis / MGI
  • abnormal cell physiology / MGI
  • early cellular replicative senescence / MGI
  • abnormal small intestinal villus morphology / MGI
  • increased megakaryocyte cell number / MGI
  • decreased skeletal muscle fiber size / MGI
  • ventricular septal defect / MGI
  • atrial septal defect / MGI
  • perimembraneous ventricular septal defect / MGI
  • myocardium hypoplasia / MGI
  • thin ventricle myocardium compact layer / MGI
  • abnormal atrioventricular septum morphology / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • decreased fibroblast proliferation / MGI
  • delayed heart development / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*
  • Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).