IMPC phenotypes (gene matching)
B6.129-Anpeptm1Afk/AfkH
| Status | Available to order |
| EMMA ID | EM:09063 |
| Citation information | RRID:IMSR_EM:09063 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Anpeptm1Afk/AfkH |
| Alternative name | Anpep |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Anpeptm1Afk |
| Gene/Transgene symbol | Anpep |
Information from provider
| Provider | Andreas Kolb |
| Provider affiliation | University of Aberdeen |
| Genetic information | The strain carries a partial deletion of the aminopeptidase N (Anpep) gene which deletes exons 2 through 9. This part of the protein contains the catalytic centre and a region identified as being involved in the binding of group 1 coronaviruses. |
| Phenotypic information | Homozygous:No overt phenotype is detected in the homozygous Anpep knock-out mice. A delay in mammary development was detected. Similar knock-outs for Anpep have shown a deficiency in tumour vascularisation. This was not assessed for this mutated allele.Heterozygous:Heterozygous mice have no detectable phenotype. |
| Breeding history | Mice were generated by Genoway by targeting in 129Sv ES cells and transfer of the modified cells into C57BL/6J hosts. These were bred onto C57BL/6J background and founder mice carrying the modified allele were received from Genoway. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
Disease and phenotype information
MGI phenotypes (allele matching)
- impaired mammary gland growth during pregnancy / MGI
MGI phenotypes (gene matching)
Literature references
- Mammary gland development is delayed in mice deficient for aminopeptidase N.;Kolb Andreas F, Sorrell David, Lassnig Caroline, Lillico Simon, Carlisle Ailsa, Neil Claire, Robinson Claire, Müller Mathias, Whitelaw C Bruce A, ;2013;Transgenic research;22;425-34; 22983824