B6;129-Lta/Tnftm1Fda/Orl
Status | Available to order |
EMMA ID | EM:00130 |
International strain name | B6;129-Lta/Tnftm1Fda/Orl |
Alternative name | LT-a TNF-a |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Lta/Tnftm1Fda, |
Gene/Transgene symbol | Lta |
Information from provider
Provider | F Dautry |
Provider affiliation | c/o CDTA-Orleans |
Phenotypic information | Mutant mice deficient in lymphotoxin A (Lta or LT-alpha) and tumor necrosis factors (Tnf or TNF-alpha) genes, by homologous recombination (insertion of neo gene with deletion of all the Lta gene and a part of the Tnf gene). The tumor necrosis factors (TNF and LTA) are important mediators of the immune and inflammatory responses. The heterozygous mice have 20- to 100-fold lower TNF levels in circulation than the wild-type mice. Moreover, the heterozygous animals have an increased bacterial load following Listeria monocytogenes infection. |
Breeding history | R1 ES cells (129/Sv); chimaeras crossed to C57BL/6 and then intercrossed. |
References |
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Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Mice heterozygous for a deletion of the tumor necrosis factor-alpha and lymphotoxin-alpha genes: biological importance of a nonlinear response of tumor necrosis factor-alpha to gene dosage.;Amiot F, Boussadia O, Cases S, Fitting C, Lebastard M, Cavaillon J M, Milon G, Dautry F, ;1997;European journal of immunology;27;1035-42; 9130661
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