B6.129-Lta/Tnftm1Fda/Orl

Status

Available to order

EMMA IDEM:01780
International strain nameB6.129-Lta/Tnftm1Fda/Orl
Alternative nametnf, lt KO (C57BL/6)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolLta/Tnftm1Fda,
Gene/Transgene symbolLta

Information from provider

ProviderGilles Marchal
Provider affiliationInstitut Pasteur
Phenotypic informationSmall size of the progeny; sometimes it is necessary to use foster mothers.
Breeding historyThe strain was backcrossed to C57BL/6 for 20 generations. It has been inbred since the 20th generation.
References
  • Mice heterozygous for a deletion of the tumor necrosis factor-alpha and lymphotoxin-alpha genes: biological importance of a nonlinear response of tumor necrosis factor-alpha to gene dosage.;Amiot F, Boussadia O, Cases S, Fitting C, Lebastard M, Cavaillon J M, Milon G, Dautry F, ;1997;European journal of immunology;27;1035-42; 9130661

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

MGI phenotypes (allele matching)
  • increased susceptibility to bacterial infection / MGI
  • decreased tumor necrosis factor secretion / MGI
  • decreased susceptibility to endotoxin shock / MGI

Literature references

  • Mice heterozygous for a deletion of the tumor necrosis factor-alpha and lymphotoxin-alpha genes: biological importance of a nonlinear response of tumor necrosis factor-alpha to gene dosage.;Amiot F, Boussadia O, Cases S, Fitting C, Lebastard M, Cavaillon J M, Milon G, Dautry F, ;1997;European journal of immunology;27;1035-42; 9130661

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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