STOCK Noto^tm1Gos/Kctt

Status	Available to order
EMMA ID	EM:10371
Citation information	RRID:IMSR_EM:10371 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	STOCK Noto^tm1Gos/Kctt
Alternative name	Nototm1Gos
Strain type	Targeted Mutant Strains : Knock-in
Allele/Transgene symbol	Noto^tm1Gos
Gene/Transgene symbol	Noto

Information from provider

Provider	Achim Gossler
Provider affiliation	Medizinische Hochschule Hannover
Genetic information	Knock-in of GFP into the Noto locus.
Phenotypic information	Homozygous: Disruption of l- r- asymmetry of visceral organs. Heterozygous: none
References	The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.;Abdelkhalek Hanaa Ben, Beckers Anja, Schuster-Gossler Karin, Pavlova Maria N, Burkhardt Hannelore, Lickert Heiko, Rossant Janet, Reinhardt Richard, Schalkwyk Leonard C, Müller Ines, Herrmann Bernhard G, Ceolin Marcelo, Rivera-Pomar Rolando, Gossler Achim, ;2004;Genes & development;18;1725-36; 15231714 The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.;Beckers Anja, Alten Leonie, Viebahn Christoph, Andre Philipp, Gossler Achim, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;15765-70; 17884984 Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.;Alten Leonie, Schuster-Gossler Karin, Beckers Anja, Groos Stephanie, Ulmer Bärbel, Hegermann Jan, Ochs Matthias, Gossler Achim, ;2012;Development (Cambridge, England);139;1276-84; 22357932
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	Karolinska Institutet, Stockholm, Sweden
Animals used for archiving	heterozygous mixed males

Disease and phenotype information

MGI phenotypes (allele matching)

short tail / MGI
decreased vertebrae number / MGI
truncated notochord / MGI
postnatal lethality / MGI
abnormal primitive node morphology / MGI
abnormal motile primary cilium morphology / MGI
decreased embryonic cilium length / MGI
abnormal embryonic cilium location or orientation / MGI
absent nodal flow / MGI

MGI phenotypes (gene matching)

abnormal vertebrae morphology / MGI
kinked tail / MGI
short tail / MGI
hindlimb paralysis / MGI
abnormal floor plate morphology / MGI
abnormal dorsal root ganglion morphology / MGI
decreased caudal vertebrae number / MGI
abnormal blood vessel morphology / MGI
abnormal somite development / MGI
abnormal left-right axis patterning / MGI
postnatal lethality / MGI
premature death / MGI
abnormal tail morphology / MGI
curly tail / MGI
absent tail / MGI
abnormal primitive node morphology / MGI
abnormal motile primary cilium morphology / MGI
fusion of vertebral bodies / MGI
decreased vertebrae number / MGI
decreased lumbar vertebrae number / MGI
truncated notochord / MGI
embryo phenotype / MGI
skeleton phenotype / MGI
abnormal sclerotome morphology / MGI
abnormal motile primary cilium physiology / MGI
decreased embryonic cilium length / MGI
abnormal embryonic cilium location or orientation / MGI
absent nodal flow / MGI

Literature references

The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation.;Abdelkhalek Hanaa Ben, Beckers Anja, Schuster-Gossler Karin, Pavlova Maria N, Burkhardt Hannelore, Lickert Heiko, Rossant Janet, Reinhardt Richard, Schalkwyk Leonard C, Müller Ines, Herrmann Bernhard G, Ceolin Marcelo, Rivera-Pomar Rolando, Gossler Achim, ;2004;Genes & development;18;1725-36; 15231714
The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.;Beckers Anja, Alten Leonie, Viebahn Christoph, Andre Philipp, Gossler Achim, ;2007;Proceedings of the National Academy of Sciences of the United States of America;104;15765-70; 17884984
Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.;Alten Leonie, Schuster-Gossler Karin, Beckers Anja, Groos Stephanie, Ulmer Bärbel, Hegermann Jan, Ochs Matthias, Gossler Achim, ;2012;Development (Cambridge, England);139;1276-84; 22357932

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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STOCK Nototm1Gos/Kctt