STOCK Tg(tetO-Pax4*R129W,-DsRed)1Brgr/Cnbc
| Status | Available to order |
| EMMA ID | EM:10596 |
| Citation information | RRID:IMSR_EM:10596 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | STOCK Tg(tetO-Pax4*R129W,-DsRed)1Brgr/Cnbc |
| Alternative name | PAX4 R129W |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(tetO-Pax4*R129W,-DsRed)1Brgr |
| Gene/Transgene symbol | Tg(tetO-Pax4*R129W,-DsRed)1Brgr |
Information from provider
| Provider | Benoit Gauthier |
| Provider affiliation | Stem Cells, Andalusian Center of Molecular Biology and Regenerative Medicine (CABIMER) |
| Genetic information | Transgenic mouse line with the potential to ubiquitously express a mutated variant of the transcription factor PAX4 (PAX4 R129W), together with the DsRed fluorescent protein reporter, under the control of TRE-pCMV inducible promoter. This mouse line should be crossed with any suitable rtTA or tTA line for tissue-specific expression, according to expression pattern of the rtTA or the tTA additional transgene. The human PAX4 R121W mutant variant has been associated as single nucleotide polymorphism (SNP) to diabetes by genome-wide association studies (GWAs). |
| Phenotypic information | Homozygous:No apparent differences in comparison with non-transgenic mouse. Good general health. Without anatomic malformations or physiological troubles. No troubles of behavior.Heterozygous:No apparent differences in comparison with non-transgenic mouse. Good general health. Without anatomic malformations or physiological troubles. No troubles of behavior. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J males |
Literature references
- In vivo conditional Pax4 overexpression in mature islet β-cells prevents stress-induced hyperglycemia in mice.;Hu He Kai Hui, Lorenzo Petra I, Brun Thierry, Jimenez Moreno Carmen M, Aeberhard Deborah, Vallejo Ortega Jorge, Cornu Marion, Thorel Fabrizio, Gjinovci Asllan, Thorens Bernard, Herrera Pedro L, Meda Paolo, Wollheim Claes B, Gauthier Benoit R, ;2011;Diabetes;60;1705-15; 21521872
- PAX4 preserves endoplasmic reticulum integrity preventing beta cell degeneration in a mouse model of type 1 diabetes mellitus.;Mellado-Gil José Manuel, Jiménez-Moreno Carmen María, Martin-Montalvo Alejandro, Alvarez-Mercado Ana Isabel, Fuente-Martin Esther, Cobo-Vuilleumier Nadia, Lorenzo Petra Isabel, Bru-Tari Eva, Herrera-Gómez Irene de Gracia, López-Noriega Livia, Pérez-Florido Javier, Santoyo-López Javier, Spyrantis Andreas, Meda Paolo, Boehm Bernhard O, Quesada Ivan, Gauthier Benoit R, ;2016;Diabetologia;59;755-65; 26813254