STOCK Ptentm Tg(Alb1-cre) Tg(Alb1-HCVN)35Sml/Orl


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International strain nameSTOCK Ptentm Tg(Alb1-cre) Tg(Alb1-HCVN)35Sml/Orl
Alternative nameHCV +/+ AlbCRE +/+ PTEN flox/flox
Strain typeTransgenic Strains
Allele/Transgene symbolTg(Alb1-cre)
Gene/Transgene symbolTg(Alb1-cre)

Information from provider

ProviderHervé LERAT
Provider affiliationEquipe 18, IMRB, Inserm U955
Genetic informationThese mice are conditionally invalidated for PTEN (exon 4 and 5 are floxed). They are also transgenic for cre recombinase (albumin promoter) and transgenic for the full hepatitis C virus (HCV) ORF (albumin promoter). They were generated by crossing FL-N/35 mice with PTEN flox/flox and Alb CRE+/+ mice. These mice are invalidated for PTEN in their liver and express all HCV proteins (genotype 1b) in their liver.
Phenotypic informationHomozygous:
Severe non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC).

Severe NASH and HCC.
ReferencesNone available
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

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Practical information

Example health report
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Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

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